Clinical outcomes after transcatheter aortic valve replacement by sex and subtype of low-flow aortic stenosis.

IF 1.4 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Invasive Cardiology Pub Date : 2026-05-04 DOI:10.25270/jic/26.00096

Eileen Galvani, Oludamilola Akinmolayemi, Srivatsan Swaminathan, Carlo Mannina, Sahil Khera, Lucy M Safi, Gilbert H L Tang, Samin K Sharma, Annapoorna S Kini, Stamatios Lerakis

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引用次数: 0

Abstract

Objectives: Prior studies suggest sex differences in clinical outcomes following transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis (AS). The authors hypothesized that among patients with low-flow aortic stenosis (LFAS), outcomes differ based on sex and subtype of LFAS: classical (cLFLG), paradoxical (pLFLG), and high gradient (LFHG).

Methods: This single-center, observational, longitudinal cohort study included adults with LFAS who underwent TAVR. Differences in clinical outcomes (all-cause mortality, heart failure hospitalization [HFH], and myocardial infarction [MI]) by subtype of LFAS within each sex were examined via Kaplan Meier curves. Log rank P-values were reported.

Results: A total of 599 patients with LFAS were followed for 12 months after TAVR. Of the male patients (n = 373), 25.2% had LFHG, 32.7% cLFLG, and 42.1% pLFLG AS. Of females (n = 226), 26.1% had LFHG, 13.3% cLFLG, and 60.6% pLFLG AS. Event rates in males were 13.1% all-cause mortality, 6.2% HFH, and 0.8% MI. Event rates in females included 6.6% all-cause mortality, 8.0% HFH, and 0 MI. In males, the LFHG vs cLFLG vs pLFLG subtypes demonstrated significant differences in time to all-cause mortality (P < .001), HFH (P = .014), and MI (P = .045).

Conclusions: In this cohort, clinical outcomes in males significantly differed by subtype of LFAS, whereas these differences were not found in females.

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经导管主动脉瓣置换术后低流量主动脉狭窄患者性别及亚型的临床疗效。

目的：先前的研究表明，严重主动脉瓣狭窄（AS）患者经导管主动脉瓣置换术（TAVR）后的临床结果存在性别差异。作者假设，在低流量主动脉瓣狭窄（LFAS）患者中，结果因性别和LFAS亚型而异：经典（cLFLG），矛盾（pLFLG）和高梯度（LFHG）。方法：这项单中心、观察性、纵向队列研究纳入了接受TAVR治疗的LFAS成人患者。临床结局（全因死亡率、心力衰竭住院率[HFH]和心肌梗死[MI]）在不同性别LFAS亚型中的差异通过Kaplan Meier曲线进行检验。报告了对数秩p值。结果：599例LFAS患者接受TAVR治疗后随访12个月。在男性患者（n = 373）中，25.2%为LFHG， 32.7%为cLFLG， 42.1%为pLFLG AS。226名女性中，26.1%为LFHG， 13.3%为cLFLG， 60.6%为pLFLG AS。男性的事件发生率为全因死亡率13.1%，HFH为6.2%，MI为0.8%。女性的事件发生率为全因死亡率6.6%，HFH为8.0%，MI为0。在男性中，LFHG、cLFLG和pLFLG亚型在全因死亡率（P < 0.001）、HFH （P = 0.014）和MI （P = 0.045）的时间上存在显著差异。结论：在这个队列中，LFAS亚型不同，男性患者的临床结果有显著差异，而女性患者没有发现这些差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Invasive Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.90

自引率

6.70%

发文量

214

审稿时长

3-8 weeks

期刊介绍： The Journal of Invasive Cardiology will consider for publication suitable articles on topics pertaining to the invasive treatment of patients with cardiovascular disease.