5-Year Surgical Success and Outcomes of XEN-45 Microstent Combined with Cataract Surgery.

IF 2.3 4区医学 Q2 OPHTHALMOLOGY

Seminars in Ophthalmology Pub Date : 2026-05-06 DOI:10.1080/08820538.2026.2667852

Büşra Yılmaz Tuğan, Büşra Kurt Musaoğlu, Nurşen Yüksel

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引用次数: 0

Abstract

Purpose: To evaluate long-term intraocular pressure (IOP), number of antiglaucoma medications (AGMs), and success after phacoemulsification combined with XEN-45 implantation (Phaco+XEN-45), and to compare these outcomes between primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PEXG).

Methods: This retrospective study included 30 patients (30 eyes; 17 POAG, 13 PEXG) who underwent Phaco+XEN-45 implantation. IOP, number of AGMs, postoperative interventions, complete or qualified surgical success (IOP of 5-18 mmHg with AGMs or independent of AGMs, respectively), and failure (failure to achieve qualified success) were evaluated at 1, 2, 3, 4, 5 years postoperatively and at the final follow-up.

Results: The median IOP at baseline was 20.5 (14.8-26.5) mmHg and decreased to 16.0 (14.8-17.3) mmHg at 5 years. The median number of AGMs decreased from 3.0 (2.0-3.3) at baseline to 2.0 (0.0-2.3) at 5-year, presenting a significant reduction at all follow-up time points (p < .001). The median IOP did not differ between POAG and PEXG during follow-up, whereas PEXG required more AGMs at 1 and 2 years (p = .048 and p = .031, respectively). Kaplan-Meier analysis showed complete success rates of 60% and 36% and qualified success rates of 100% and 96%, at 1 and 5 years, respectively; with 70% qualified success rate at 8 years. Long-term success did not differ between the POAG and PEXG groups.

Conclusion: Phaco+XEN-45 implantation offers a significant reduction in AGMs and a marked decrease in IOP, with an acceptable long-term efficacy and safety profile. The similarity in the success rates of POAG and PEXG suggests that Phaco+XEN-45 is a feasible and safe option for both types of glaucoma with appropriate patient selection and effective postoperative bleb modulation.

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XEN-45微支架联合白内障手术的5年手术成功率和疗效。

目的：评价超声乳化术联合XEN-45植入术（Phaco+XEN-45）后的长期眼压（IOP）、抗青光眼药物（AGMs）数量和成功率，并比较原发性开角型青光眼（POAG）和假性剥脱型青光眼（PEXG）的这些结果。方法：回顾性研究采用Phaco+XEN-45植入术的患者30例（30眼，POAG 17眼，PEXG 13眼）。在术后1年、2年、3年、4年、5年和最后随访时评估IOP、agm数量、术后干预、完全或合格的手术成功（IOP分别为5-18 mmHg伴有agm或独立于agm）和失败（未能获得合格的成功）。结果：基线时的中位IOP为20.5 (14.8-26.5)mmHg， 5年后降至16.0 (14.8-17.3)mmHg。AGMs中位数从基线时的3.0例（2.0-3.3例）降至5年时的2.0例（0.0-2.3例），在所有随访时间点均有显著降低（p p =）。048和p =。031年,分别)。Kaplan-Meier分析显示，1年和5年的完全成功率分别为60%和36%，合格成功率分别为100%和96%；8年合格率70%。POAG组和PEXG组的长期疗效没有差异。结论：Phaco+XEN-45植入术可显著降低agm和IOP，具有可接受的长期疗效和安全性。POAG和PEXG的成功率相似，提示Phaco+XEN-45是两种类型青光眼的可行和安全的选择，患者选择适当，术后有效的水泡调节。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in Ophthalmology OPHTHALMOLOGY-

CiteScore

3.20

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Seminars in Ophthalmology offers current, clinically oriented reviews on the diagnosis and treatment of ophthalmic disorders. Each issue focuses on a single topic, with a primary emphasis on appropriate surgical techniques.