Christine Rode Schwarz, Tina Vilsbøll, Malene Ø Aistrup, Julie T Kloppenborg
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引用次数: 0
Abstract
We present 2 case reports of the benefits of the subcutaneous once-weekly glucagon-like peptide 1 receptor agonist (GLP-1RA) therapy semaglutide in adolescents with type 1 diabetes (T1D) complicated by obesity. Two female individuals (17 and 12 years old) with T1D who have automated and continuous insulin delivery systems presented with marked weight gain, increasing insulin requirement, and suboptimal glycemic control. We added GLP-1RA to standard insulin pump therapy and revisited education related to healthy lifestyle. Both adolescents achieved notable improvements in glycemic control, weight, and insulin requirement after 12 months of treatment without any adverse events. These cases suggest that adjunctive GLP-1RA therapy may improve metabolic control and body weight management in adolescent T1D with obesity. Larger studies are needed to clarify optimal dosing and safety, including long-term effects on body composition and growth.
期刊介绍：
The Pediatrics® journal is the official flagship journal of the American Academy of Pediatrics (AAP). It is widely cited in the field of pediatric medicine and is recognized as the leading journal in the field.
The journal publishes original research and evidence-based articles, which provide authoritative information to help readers stay up-to-date with the latest developments in pediatric medicine. The content is peer-reviewed and undergoes rigorous evaluation to ensure its quality and reliability.
Pediatrics also serves as a valuable resource for conducting new research studies and supporting education and training activities in the field of pediatrics. It aims to enhance the quality of pediatric outpatient and inpatient care by disseminating valuable knowledge and insights.
As of 2023, Pediatrics has an impressive Journal Impact Factor (IF) Score of 8.0. The IF is a measure of a journal's influence and importance in the scientific community, with higher scores indicating a greater impact. This score reflects the significance and reach of the research published in Pediatrics, further establishing its prominence in the field of pediatric medicine.
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