Spirometry Assessments in Children With Sickle Cell Disease in Ghana.

IF 2.3 3区医学 Q1 PEDIATRICS

Pediatric Pulmonology Pub Date : 2026-05-01 DOI:10.1002/ppul.71655

Baah Agyeiwah Birgit, Ntim Amankwa Emmanuel, Osei Eugenia, Paintsil Vivian, Marfo Joseph, Marozva Nicola, Osei Akoto Alex, Ansong Daniel, Gray Diane, Kwarteng-Owusu Sandra

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引用次数: 0

Abstract

Background: Pulmonary disease in children with SCD is common and heterogeneous and includes pulmonary function impairment. This study aimed to investigate spirometry patterns in Ghanaian children with SCD and factors that contribute to low lung function.

Methods: A case-control study involving children aged 6-16 years with and without SCD was carried out at the Komfo Anokye Teaching Hospital. Demographic, socio-economic, and clinical information were collected. Spirometry was performed for both cases and controls at enrolment and interpreted based on the GLI-Black reference equation. Logistic and linear regression analyses were performed.

Results: A total of 115 cases and 115 controls were recruited for the study. Children with SCD had significantly lower anthropometric measurements, lower lung volumes compared to the controls: median (IQR) BMI z-scores; cases vs controls, -0.5 (-1.3 to 0.3); versus -0.2 (-0.9 to 0.8) p = 0.01, mean z- scores for forced expiratory volume in 1 s (FEV₁₎, cases vs controls, -1.0 (SD1.2) vs -0.4 (SD 1.2) z-score, (p < 0.001), mean z-scores for forced vital capacity (FVC z-scores), cases versus controls, -0.8 (SD1.2) z score vs -0.3 (SD 1.3) z-score, (p < 0.001). Abnormal lung function was significantly more common in cases than controls, 42% (n = 48) and 17.4% (n = 20) respectively. The lung function abnormalities noted were as follows: restrictive pattern, cases versus controls [24.3% (n = 28) vs 12.2% (n = 14)] (p < 0.001), obstructive pattern [14.8% (n = 17) versus 5.2% (n = 6)] (p < 0.001), mixed pattern [2.6% (n = 3) versus 0 (p < 0.001). Being female and having higher BMI z-scores were associated with significantly lower odds of having a restrictive lung function pattern compared to normal lung function, OR 0.31 (95% CI 0.16, 0.58) (p < 0.001).

Conclusion: This study has demonstrated a predominance of low anthropometric measurements and restrictive abnormality on spirometry in children with SCD in Ghana. Females and those with higher BMI z-scores had significantly lower odds of having a restrictive lung function pattern compared to normal lung function.

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加纳镰状细胞病儿童肺活量测定评估

背景：SCD患儿肺部疾病是常见且异质性的，包括肺功能损害。本研究旨在调查加纳SCD儿童的肺活量测定模式和导致肺功能低下的因素。方法：在Komfo Anokye教学医院进行了一项涉及6-16岁患有和不患有SCD的儿童的病例对照研究。收集了人口统计、社会经济和临床信息。在入组时对病例和对照组进行肺活量测定，并根据glii - black参考方程进行解释。进行了Logistic和线性回归分析。结果：共纳入115例病例和115例对照组。与对照组相比，SCD患儿的人体测量值显著降低，肺体积更小：中位数（IQR） BMI z分数；病例vs对照组，-0.5 (-1.3 ~ 0.3)；对比-0.2(-0.9至0.8)p = 0.01, 1秒内用力呼气量（FEV1）的平均z-评分，病例vs对照组，-1.0 (SD1.2) vs -0.4 (SD1.2) z-评分，(p)结论：本研究表明加纳SCD患儿的人体测量值偏低和肺活量测定法限制性异常占主导地位。与正常肺功能相比，女性和BMI z分数较高的人患限制性肺功能模式的几率明显较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Pulmonology 医学-呼吸系统

CiteScore

6.00

自引率

12.90%

发文量

468

审稿时长

3-8 weeks

期刊介绍： Pediatric Pulmonology (PPUL) is the foremost global journal studying the respiratory system in disease and in health as it develops from intrauterine life though adolescence to adulthood. Combining explicit and informative analysis of clinical as well as basic scientific research, PPUL provides a look at the many facets of respiratory system disorders in infants and children, ranging from pathological anatomy, developmental issues, and pathophysiology to infectious disease, asthma, cystic fibrosis, and airborne toxins. Focused attention is given to the reporting of diagnostic and therapeutic methods for neonates, preschool children, and adolescents, the enduring effects of childhood respiratory diseases, and newly described infectious diseases. PPUL concentrates on subject matters of crucial interest to specialists preparing for the Pediatric Subspecialty Examinations in the United States and other countries. With its attentive coverage and extensive clinical data, this journal is a principle source for pediatricians in practice and in training and a must have for all pediatric pulmonologists.