Chemical constituents and ferroptosis inhibitory activity of the deep-sea-derived fungus Penicillium citrinum W24.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2026-05-07 DOI:10.1080/14786419.2026.2669680

Cheng-You Lin, Yuan Wang, Tai-Zong Wu, Rong Chao, Zheng-Biao Zou, Li-Sheng Li, Tian-Hua Zhong, Xian-Wen Yang

引用次数: 0

Abstract

One new citrinin derivative (1) and one new fatty acid (27) were isolated from the marine Penicillium citrinum W24, together with 29 known compounds. Their structures were determined by extensive spectroscopic analysis. Compound 7 showed potent ferroptosis inhibitory activity with an EC₅₀ value of 0.22 μM.

查看原文本刊更多论文

深海来源真菌青霉W24的化学成分及抑制铁下垂活性。

从海洋柑橘青霉W24中分离到1个新的柑橘酸衍生物(1)和1个新的脂肪酸（27），以及29个已知化合物。通过广泛的光谱分析确定了它们的结构。化合物7具有较强的抑制铁下垂活性，EC50值为0.22 μM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.