Impact of nosocomial infections on neurodevelopmental outcome and rehospitalization rate in preterm infants with birth weight below 1500 g (NINO study).

IF 2.4 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Journal of Perinatology Pub Date : 2026-05-05 DOI:10.1038/s41372-026-02681-2

Elisabeth Resch-Poteralski, Ute Maurer-Fellbaum, Julia Eichberger, Volker Strenger, Robert Krause, Elisabeth Pichler-Stachl, Alexander Avian, Bernhard Resch, Berndt Urlesberger

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引用次数: 0

Abstract

Objective: This study aimed to determine the influence of nosocomial bacterial and viral infections of preterm very low birth weight (VLBW) infants on neurodevelopmental outcome and on rehospitalization rates during the first two years of life.

Study design: Retrospective single-center cohort study including preterm infant born between 2010 and 2018 and followed until two years of age corrected for prematurity (Bayley scales).

Results: Of 620 study infants 418 without neurodevelopmental impairment (NDI). were compared to 202 infants with NDI. Single or multiple nosocomial infections were not risk factors for NDI in a multivariate logistic regression model checked for multicollinearity. Infants with NDI were of younger gestational age, had lower birth weights and higher rates of neonatal complications (ileus, periventricular leukomalacia, and bronchopulmonary dysplasia). Nosocomial infection were also not risk factors for rehospitalizations by infectious diseases.

Conclusions: Nosocomial infections did not significantly influence NDI and rehospitalization rates in preterm VLBW infants.

Trial registration number: The study was registered at "Deutsches Register Klinischer Studien" DRKS00019000.

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医院感染对出生体重低于1500 g的早产儿神经发育结局和再住院率的影响（NINO研究）。

目的：本研究旨在确定医院内细菌和病毒感染对极低出生体重（VLBW）早产儿神经发育结局和出生后头两年再住院率的影响。研究设计：回顾性单中心队列研究，包括2010年至2018年间出生的早产儿，并随访至两岁（贝利量表）校正早产。结果：620名研究婴儿中，418名无神经发育障碍（NDI）。与202名NDI婴儿进行比较。在多重共线性检验的多变量logistic回归模型中，单一或多个医院感染不是NDI的危险因素。NDI婴儿胎龄较低，出生体重较低，新生儿并发症（肠梗阻、脑室周围白质软化和支气管肺发育不良）发生率较高。医院感染也不是感染性疾病再住院的危险因素。结论：院内感染对VLBW早产儿NDI和再住院率无显著影响。试验注册号：本研究注册号为“Deutsches Register Klinischer studen”DRKS00019000。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Perinatology 医学-妇产科学

CiteScore

5.40

自引率

6.90%

发文量

284

审稿时长

3-8 weeks

期刊介绍： The Journal of Perinatology provides members of the perinatal/neonatal healthcare team with original information pertinent to improving maternal/fetal and neonatal care. We publish peer-reviewed clinical research articles, state-of-the art reviews, comments, quality improvement reports, and letters to the editor. Articles published in the Journal of Perinatology embrace the full scope of the specialty, including clinical, professional, political, administrative and educational aspects. The Journal also explores legal and ethical issues, neonatal technology and product development. The Journal’s audience includes all those that participate in perinatal/neonatal care, including, but not limited to neonatologists, perinatologists, perinatal epidemiologists, pediatricians and pediatric subspecialists, surgeons, neonatal and perinatal nurses, respiratory therapists, pharmacists, social workers, dieticians, speech and hearing experts, other allied health professionals, as well as subspecialists who participate in patient care including radiologists, laboratory medicine and pathologists.