Clonal hematopoiesis in lung adenocarcinoma pathogenesis.

IF 6.1 1区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

JCI insight Pub Date : 2026-05-08 DOI:10.1172/jci.insight.203981

Tiziana Parisi, Blanca Santibanez Ocampo, Jacob Adelman, Yuyan Cai, Marie McConkey, Christopher J Gibson, Benjamin L Ebert, Peter Miller, Tyler Jacks

引用次数: 0

Abstract

Age-related blood cell mutations (clonal hematopoiesis) reshape immune cells and lung tumor immune structures, but did not increase lung cancer growth in a genetically engineered mouse model.

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克隆造血在肺腺癌发病机制中的作用。

年龄相关的血细胞突变（克隆造血）重塑免疫细胞和肺肿瘤免疫结构，但在基因工程小鼠模型中没有增加肺癌的生长。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JCI insight Medicine-General Medicine

CiteScore

13.70

自引率

1.20%

发文量

543

审稿时长

6 weeks

期刊介绍： JCI Insight is a Gold Open Access journal with a 2022 Impact Factor of 8.0. It publishes high-quality studies in various biomedical specialties, such as autoimmunity, gastroenterology, immunology, metabolism, nephrology, neuroscience, oncology, pulmonology, and vascular biology. The journal focuses on clinically relevant basic and translational research that contributes to the understanding of disease biology and treatment. JCI Insight is self-published by the American Society for Clinical Investigation (ASCI), a nonprofit honor organization of physician-scientists founded in 1908, and it helps fulfill the ASCI's mission to advance medical science through the publication of clinically relevant research reports.

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