Predictive Value of Residual Cholesterol Inflammatory Index for Left Atrial Thrombus or Spontaneous Echo Contrast in Patients with Nonvalvular Atrial Fibrillation with Low CHA₂DS₂-VASc Scores.

IF 2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

International Journal of General Medicine Pub Date : 2026-04-30 eCollection Date: 2026-01-01 DOI:10.2147/IJGM.S604377

Jiaqi Wang, Yaqiong Jin, Li Wang, Yunmeng Wang, Jingchao Lu

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引用次数: 0

Abstract

Background: Left atrial thrombus (LAT) is the main cause of ischemic stroke in patients with atrial fibrillation. Left atrial thrombus or spontaneous echo contrast (SEC) can be best displayed by transesophageal echocardiography (TEE). This study aimed to evaluate non-valvular atrial fibrillation (NVAF) patients with LAT/SEC confirmed by transesophageal echocardiography compared with those without LAT/SEC, using residual cholesterol inflammatory index (RCII) as a sensitive biomarker.

Methods: This study was a retrospective study of 967 NVAF patients who underwent transesophageal echocardiography at a single center. Patients were divided into two groups based on the presence or absence of LAT/SEC on TEE. The levels of RCII and left atrium diameter (LAD) were compared.

Results: RCII was identified as an independent variable in patients with LAT/SEC detected by transesophageal echocardiography. (OR: 1.232, CI:1.159-1.309, p < 0.001) The combination of RCII, LAD, and CHA2DS2-VASc scores had the highest area under the curve (AUC) value (AUC:0.787 CI:0.748-0.826 p <0.001).

Conclusion: Our study demonstrates that RCII and LAD are risk factors for LAT/SEC. CHA2DS2-VASc score combined with RCII and LAD can significantly improve the predictive ability of LAT/SEC.

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低CHA2DS2-VASc评分的非瓣膜性房颤患者剩余胆固醇炎症指数对左房血栓或自发回声造影的预测价值

背景：左心房血栓（LAT）是心房颤动患者发生缺血性脑卒中的主要原因。经食管超声心动图（TEE）可以很好地显示左房血栓或自发性回声造影剂（SEC）。本研究旨在评价经食管超声心动图证实LAT/SEC的非瓣膜性心房颤动（NVAF）患者与无LAT/SEC患者的比较，使用残余胆固醇炎症指数（RCII）作为敏感的生物标志物。方法：本研究是一项回顾性研究，967例非瓣膜性房颤患者在单中心接受了经食管超声心动图检查。根据TEE是否存在LAT/SEC将患者分为两组。比较RCII水平和左心房直径（LAD）。结果：RCII是经食管超声心动图检测LAT/SEC患者的自变量。（OR: 1.232, CI:1.159 ~ 1.309, p < 0.001） RCII、LAD和CHA2DS2-VASc评分组合的曲线下面积（AUC）值最高（AUC:0.787 CI:0.748 ~ 0.826 p）。结论：我们的研究表明RCII和LAD是LAT/SEC的危险因素。CHA2DS2-VASc评分联合RCII、LAD可显著提高LAT/SEC的预测能力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.