The Serum Platelet-Albumin Ratio in Hyperemesis Gravidarum: A Retrospective Comparative Study.

IF 2.6 4区医学 Q2 OBSTETRICS & GYNECOLOGY

International Journal of Women's Health Pub Date : 2026-05-02 eCollection Date: 2026-01-01 DOI:10.2147/IJWH.S595508

Osman Ince, Esra Ince

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引用次数: 0

Abstract

Purpose: This study aimed to evaluate the association between platelet-to-albumin ratio (PAR) and hyperemesis gravidarum (HG), and to assess its potential diagnostic value.

Patients and methods: This retrospective comparative study was conducted at a tertiary obstetrics center between January 2024 and December 2025. A total of 160 pregnant women were included (80 with HG and 80 healthy controls). Demographic, clinical, and laboratory parameters were analyzed.

Results: Gravidity and parity differed significantly between groups (p<0.001). Among laboratory parameters, TSH (1.64±0.53 vs 1.20±0.39, p=0.006), potassium (4.06±0.41 vs 3.95±0.43, p=0.003), albumin (42.69±5.72 vs 39.59±8.56, p<0.001), and PAR (6.15±1.49 vs 9.26±2.89, p<0.001) were significantly different. ROC analysis demonstrated that PAR had a cut-off value of ≥6.51 for predicting HG (AUC = 0.825, 95% CI: 0.74-0.88), with 82.1% sensitivity and 66.2% specificity. The positive predictive value (PPV) was 80.9% and the negative predictive value (NPV) was 79.1%.

Conclusion: PAR levels were significantly elevated in patients with HG and may serve as a simple and accessible biomarker. However, larger prospective studies are required to validate these findings.

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妊娠剧吐患者血清血小板-白蛋白比值的回顾性比较研究。

目的：探讨血小板白蛋白比（PAR）与妊娠剧吐（HG）的关系，并探讨其潜在的诊断价值。患者和方法：本回顾性比较研究于2024年1月至2025年12月在一家三级产科中心进行。总共包括160名孕妇（80名HG患者和80名健康对照）。分析了人口统计学、临床和实验室参数。结果：妊娠和胎次在两组间差异显著(p结论：PAR水平在HG患者中显著升高，可能作为一种简单易懂的生物标志物。然而，需要更大规模的前瞻性研究来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Women's Health OBSTETRICS & GYNECOLOGY-

CiteScore

3.70

自引率

0.00%

发文量

194

审稿时长

16 weeks

期刊介绍： International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.