Bayesian benchmark dose assessment of fluoride exposure and renal function impairment in adolescents.

IF 1.9 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2026-05-04 DOI:10.1080/09603123.2026.2667879

Lei Wu, Shirui Yan, Rui Zhang, Paula Fiorella Chacon Campoverde, Ailin Li, Zhe Mo, Xinxiao Li, Di Wu, Nian Gao, Xiaowei Wang, Minghan Luo, Junrui Pei

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引用次数: 0

Abstract

Adolescents are highly susceptible to fluoride toxicity, yet evidence on renal effects and safety thresholds is limited and inconsistent. Data from adolescents aged 12-19 years in the 2015-2016 National Health and Nutrition Examination Survey (NHANES) were used in this study. The sample sizes were 1,042 for urinary fluoride (UF), 1,062 for plasma fluoride (PF), and 916 for drinking-water fluoride (WF). We analyzed associations between fluoride exposure (UF, PF, and WF) and renal function. Methods included survey-weighted linear/logistic regression, restricted cubic splines (RCS), inverse probability treatment weighting, trend tests, and Bayesian Benchmark Dose modeling (BBMD). RCS indicated linear relationships (P-nonlinear >0.05). Weighted linear regression showed significant inverse associations of UF (β = -11.16 (-20.10, -2.22), P = 0.029) and PF (β = -5.04 (-9.45, -0.62), P = 0.036) with estimated glomerular filtration rate; WF was non-significant (P = 0.585). The 10% benchmark concentration (BMC₁₀) for UF was 1.63 mg/L (10% Benchmark Concentration Lower bound (BMCL₁₀): 1.25 mg/L); for PF, BMC₁₀ was 0.46 μmol/L (BMCL₁₀: 0.24 μmol/L). These renal BMC values were lower than bone-derived benchmarks. Future regulations on environmental fluoride exposure should consider non-skeletal health effects in vulnerable populations.

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青少年氟暴露与肾功能损害的贝叶斯基准剂量评估。

青少年对氟化物毒性非常敏感，但关于肾脏影响和安全阈值的证据有限且不一致。本研究使用2015-2016年全国健康与营养检查调查（NHANES）中12-19岁青少年的数据。尿氟化物（UF）的样本量为1042，血浆氟化物（PF）的样本量为1062，饮用水氟化物（WF）的样本量为916。我们分析了氟化物暴露（UF、PF和WF）与肾功能之间的关系。方法包括调查加权线性/逻辑回归、限制性三次样条（RCS）、反概率处理加权、趋势检验和贝叶斯基准剂量模型（BBMD）。RCS呈线性关系（p -非线性>.05）。加权线性回归显示UF （β = -11.16 (-20.10, -2.22), P = 0.029）和PF （β = -5.04 (-9.45, -0.62), P = 0.036）与肾小球滤过率呈显著负相关；WF差异无统计学意义（P = 0.585）。用友10%基准浓度（BMC10）为1.63 mg/L(10%基准浓度下限（BMCL10）： 1.25 mg/L)；BMC10为0.46 μmol/L (BMCL10为0.24 μmol/L)；这些肾BMC值低于骨源性基准。未来关于环境氟化物暴露的法规应考虑对脆弱人群的非骨骼健康的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.