Effects of kaempferol on bone loss in animal models of osteoporosis: a systematic review and meta-analysis.

IF 4.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2026-04-22 eCollection Date: 2026-01-01 DOI:10.3389/fendo.2026.1805337

Guangming Kang, Dechun Qu, Bo Dong, Rui Tang, Xin Liu, Shihang Cao, Dongping Wan, Haoxiang Yuan, Chuan Leng, Rui Wang, Baohui Wang

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引用次数: 0

Abstract

Purpose: Osteoporosis remains a major global health challenge, necessitating the search for safe and effective therapeutic leads. Kaempferol, a natural flavonoid, has shown potential in bone health management. This systematic review and meta-analysis aimed to quantitatively evaluate the preclinical efficacy of kaempferol in mitigating bone loss in animal models of osteoporosis.

Methods: Following PRISMA guidelines and PROSPERO registration (CRD420251273304), a comprehensive search was conducted across eight electronic databases up to January 2026. Twelve randomized controlled trials investigating kaempferol monotherapy in osteoporotic animal models (primarily OVX rats) were included. Methodological quality was assessed using SYRCLE's risk of bias tool, and meta-analysis was performed using Stata 18.0.

Results: Kaempferol significantly increased femoral bone mineral density (BMD) (SMD = 2.86; 95% CI: 1.96-3.79; p < 0.001). It also significantly improved microarchitectural parameters (BV/TV, Tb.N, Tb.Th) and biomechanical properties (elastic modulus). Mechanistically, kaempferol elevated bone formation markers (P1NP), suppressed bone resorption markers (TRACP, CTX), and modulated the RANKL/OPG signaling axis. Subgroup analyses confirmed consistent osteoprotective effects across various dosages and intervention durations.

Conclusion: Preclinical evidence robustly demonstrates that kaempferol effectively preserves bone mass and microarchitectural integrity while enhancing mechanical strength. These findings establish kaempferol as a promising natural bioactive candidate for osteoporosis management and provide a rigorous evidence-based foundation for its clinical translation.

Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD420251273304.

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山奈酚对骨质疏松动物模型骨质流失的影响：系统回顾和荟萃分析。

目的：骨质疏松症仍然是一个主要的全球健康挑战，需要寻找安全有效的治疗线索。山奈酚是一种天然类黄酮，已显示出在骨骼健康管理方面的潜力。本系统综述和荟萃分析旨在定量评价山奈酚在骨质疏松动物模型中减轻骨质流失的临床前疗效。方法：遵循PRISMA指南和PROSPERO注册（CRD420251273304），对截至2026年1月的8个电子数据库进行全面检索。纳入了12项随机对照试验，研究山奈酚单药治疗骨质疏松动物模型（主要是OVX大鼠）。使用sycle的偏倚风险工具评估方法学质量，使用Stata 18.0进行meta分析。结果：山奈酚显著提高股骨骨密度（BMD）（SMD = 2.86; 95% CI: 1.96 ~ 3.79; p < 0.001）。它还显著提高了微结构参数(BV/TV, Tb。N,结核病。Th)和生物力学性能（弹性模量）。在机制上，山奈酚提高骨形成标志物（P1NP），抑制骨吸收标志物（TRACP， CTX），并调节RANKL/OPG信号轴。亚组分析证实了不同剂量和干预持续时间的骨保护作用。结论：临床前证据有力地证明山奈酚能有效地保持骨量和微结构完整性，同时提高机械强度。这些发现确立了山奈酚作为一种有前途的天然生物活性候选物用于骨质疏松症的治疗，并为其临床转化提供了严格的循证基础。系统评审注册：https://www.crd.york.ac.uk/prospero/，标识符CRD420251273304。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.