Mechanisms of dyslipidemia-induced erectile dysfunction: a narrative review.

IF 4.6 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Frontiers in Endocrinology Pub Date : 2026-04-22 eCollection Date: 2026-01-01 DOI:10.3389/fendo.2026.1780243

Dicheng Luo, Di Sun, Elena Colonnello, Li-Ping Pan, Shuang Wu, Jun Guo, Hao Wang, Jiwei Zhang

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引用次数: 0

Abstract

Background: Dyslipidemia is strongly associated with obesity, metabolic syndrome, and atherosclerosis, and is increasingly recognized as an independent risk factor for erectile dysfunction (ED). Emerging evidence suggests lipid-specific mechanisms that may directly impair erectile function, beyond the effects of obesity.

Objective: To summarize the pathophysiological mechanisms linking dyslipidemia to the development and progression of ED.

Methods: A narrative review of studies published between 2000 and 2025 was conducted using PubMed, Web of Science, Scopus, and Google Scholar, including experimental, clinical, observational, and review studies.

Results and conclusion: Dyslipidemia contributes to ED through multiple interconnected pathways, including vascular dysfunction, neural impairment, oxidative stress, inflammation, and endocrine alterations. These mechanisms may increase susceptibility to ED in affected patients. However, direct evidence remains limited, and confounding by coexisting metabolic, cardiovascular and neural conditions complicates interpretation. Further research is needed to clarify the independent effects of dyslipidemia and to identify potential therapeutic strategies.

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血脂异常引起勃起功能障碍的机制：一个叙述性的回顾。

背景：血脂异常与肥胖、代谢综合征和动脉粥样硬化密切相关，并且越来越被认为是勃起功能障碍（ED）的独立危险因素。越来越多的证据表明，除了肥胖的影响外，脂质特异性机制可能直接损害勃起功能。目的：总结血脂异常与ed发生发展的病理生理机制。方法：对2000年至2025年间发表在PubMed、Web of Science、Scopus和谷歌Scholar等网站上的相关研究进行综述，包括实验、临床、观察和综述研究。结果与结论：血脂异常通过多种相互关联的途径导致ED，包括血管功能障碍、神经损伤、氧化应激、炎症和内分泌改变。这些机制可能会增加患者对ED的易感性。然而，直接证据仍然有限，并且共存的代谢、心血管和神经疾病使解释复杂化。需要进一步的研究来阐明血脂异常的独立影响，并确定潜在的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Endocrinology Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

5.70

自引率

9.60%

发文量

3023

审稿时长

14 weeks

期刊介绍： Frontiers in Endocrinology is a field journal of the "Frontiers in" journal series. In today’s world, endocrinology is becoming increasingly important as it underlies many of the challenges societies face - from obesity and diabetes to reproduction, population control and aging. Endocrinology covers a broad field from basic molecular and cellular communication through to clinical care and some of the most crucial public health issues. The journal, thus, welcomes outstanding contributions in any domain of endocrinology. Frontiers in Endocrinology publishes articles on the most outstanding discoveries across a wide research spectrum of Endocrinology. The mission of Frontiers in Endocrinology is to bring all relevant Endocrinology areas together on a single platform.