Shudan Deng, Haixia Fan, Lu Zhai, Limantian Wang, Yan Li, Bomeng Zhao, Huiyan Niu, Xiaoling Gao
{"title":"Scientific trends in obstructive sleep apnea biological and clinical assessment indicators: a bibliometric analysis.","authors":"Shudan Deng, Haixia Fan, Lu Zhai, Limantian Wang, Yan Li, Bomeng Zhao, Huiyan Niu, Xiaoling Gao","doi":"10.1080/17520363.2026.2671003","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>Obstructive sleep apnea (OSA) is characterized by diverse biological and clinical disturbances, yet no study has systematically examined scientific developments related to its objective assessment measures. This study aimed to map the development, research hotspots, and emerging trends related to biological and clinical assessment indicators in OSA.</p><p><strong>Materials and methods: </strong>Publications indexed in the Web of Science Core Collection and Scopus from 2000 to 2025 were reviewed. A total of 1,793 articles were analyzed using VOSviewer, CiteSpace, the R bibliometrix package, and Python. The analysis assessed publication and citation trends, country contributions, keyword co-occurrence, and thematic evolution to map global research patterns in OSA assessment.</p><p><strong>Results: </strong>The number of publications increased steadily over time, reflecting growing research interest in multidimensional assessment approaches. Research themes have evolved from general inflammatory and metabolic markers toward more mechanistic and clinically oriented indicators, including oxidative stress pathways, circulating biomarkers, and cerebrovascular or cognitive related measures.</p><p><strong>Conclusions: </strong>Current research increasingly emphasizes integrated biological and clinical assessment frameworks for better characterization of OSA. Future studies should focus on validation, methodological standardization, and the integration of multiple assessment domains to facilitate clinical translation.</p>","PeriodicalId":9182,"journal":{"name":"Biomarkers in medicine","volume":" ","pages":"1-13"},"PeriodicalIF":2.1000,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomarkers in medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17520363.2026.2671003","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Aims: Obstructive sleep apnea (OSA) is characterized by diverse biological and clinical disturbances, yet no study has systematically examined scientific developments related to its objective assessment measures. This study aimed to map the development, research hotspots, and emerging trends related to biological and clinical assessment indicators in OSA.
Materials and methods: Publications indexed in the Web of Science Core Collection and Scopus from 2000 to 2025 were reviewed. A total of 1,793 articles were analyzed using VOSviewer, CiteSpace, the R bibliometrix package, and Python. The analysis assessed publication and citation trends, country contributions, keyword co-occurrence, and thematic evolution to map global research patterns in OSA assessment.
Results: The number of publications increased steadily over time, reflecting growing research interest in multidimensional assessment approaches. Research themes have evolved from general inflammatory and metabolic markers toward more mechanistic and clinically oriented indicators, including oxidative stress pathways, circulating biomarkers, and cerebrovascular or cognitive related measures.
Conclusions: Current research increasingly emphasizes integrated biological and clinical assessment frameworks for better characterization of OSA. Future studies should focus on validation, methodological standardization, and the integration of multiple assessment domains to facilitate clinical translation.
期刊介绍：
Biomarkers are physical, functional or biochemical indicators of physiological or disease processes. These key indicators can provide vital information in determining disease prognosis, in predicting of response to therapies, adverse events and drug interactions, and in establishing baseline risk. The explosion of interest in biomarker research is driving the development of new predictive, diagnostic and prognostic products in modern medical practice, and biomarkers are also playing an increasingly important role in the discovery and development of new drugs. For the full utility of biomarkers to be realized, we require greater understanding of disease mechanisms, and the interplay between disease mechanisms, therapeutic interventions and the proposed biomarkers. However, in attempting to evaluate the pros and cons of biomarkers systematically, we are moving into new, challenging territory.
Biomarkers in Medicine (ISSN 1752-0363) is a peer-reviewed, rapid publication journal delivering commentary and analysis on the advances in our understanding of biomarkers and their potential and actual applications in medicine. The journal facilitates translation of our research knowledge into the clinic to increase the effectiveness of medical practice.
As the scientific rationale and regulatory acceptance for biomarkers in medicine and in drug development become more fully established, Biomarkers in Medicine provides the platform for all players in this increasingly vital area to communicate and debate all issues relating to the potential utility and applications.
Each issue includes a diversity of content to provide rounded coverage for the research professional. Articles include Guest Editorials, Interviews, Reviews, Research Articles, Perspectives, Priority Paper Evaluations, Special Reports, Case Reports, Conference Reports and Company Profiles. Review coverage is divided into themed sections according to area of therapeutic utility with some issues including themed sections on an area of topical interest.
Biomarkers in Medicine provides a platform for commentary and debate for all professionals with an interest in the identification of biomarkers, elucidation of their role and formalization and approval of their application in modern medicine. The audience for Biomarkers in Medicine includes academic and industrial researchers, clinicians, pathologists, clinical chemists and regulatory professionals.
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