Natalia L Rosa-Padilla, Brenley Fuller, Cambrie Schumacher, Cassie Lux, Kelley Thieman, Kathryn Biehl, Kathleen Ham
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引用次数: 0
Abstract
Objective: To report the proportion of cases, causes, and definitions of recurrent and persistent hypercalcemia in dogs following surgical removal of autonomously functioning parathyroid tissue.
Methods: Retrospective review of medical records from 3 academic veterinary hospitals (2012 to 2022) identified dogs with surgically treated primary hyperparathyroidism. Data included signalment, clinical signs, diagnostics, treatment, histopathology, and outcomes. Dogs were categorized by follow-up: ≤ 6 months (group 1) or > 6 months (group 2). Descriptive statistics were performed. The Mann-Whitney U test compared preoperative ionized calcium and parathyroid hormone between dogs with persistent versus resolved hypercalcemia.
Results: 202 dogs met the inclusion criteria. Group 1 included 123 dogs, and group 2 included 79 dogs. Mean age was 10.7 ± 2.23 years, with no sex predilection. Hypercalcemia-associated clinical signs occurred in 68% (138 of 202) of dogs. Histopathology revealed parathyroid adenoma (58% [135 of 233]), hyperplasia (24% [56 of 233]), and carcinoma (7% [10 of 233]) as most common. Persistent hypercalcemia occurred in 25 of 202 dogs (12.4%), primarily due to incorrect surgical removal or multiglandular disease. Preoperative ionized calcium and parathyroid hormone did not differ between persistent and resolved cases. Recurrent hypercalcemia occurred in 1 of 79 (1.3%) dogs in group 2, associated with a new mass. Fifteen dogs underwent a second surgery; 1 dog required a third surgery.
Conclusions: Persistent and recurrent hypercalcemia were uncommon (12.4% and 1.3%, respectively). Multiglandular disease and incorrect surgical excision were the leading causes of persistent hypercalcemia.
Clinical relevance: This study emphasizes that persistent and recurrent hypercalcemia are uncommon but require diligent perioperative planning and monitoring.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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