Trachoma Prevalence in Al Rahad Locality, Sudan: Evaluating Chlamydia trachomatis Infection Prevalence as a Complementary Programmatic Indicator.

IF 1.6 4区医学 Q3 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

American Journal of Tropical Medicine and Hygiene Pub Date : 2026-05-05 DOI:10.4269/ajtmh.26-0096

Scott D Nash, Emmanuel A Ackah, Balgesa E Elshafie, Zeinab Abdalla, Sara Lavinia Brair, Tania A Gonzalez, Charles A Rivers, Barbara Van Der Pol, E Kelly Callahan, Angelia M Sanders

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引用次数: 0

Abstract

Trachoma remains endemic in Sudan. A 2009 baseline survey in Al Rahad locality revealed a trachomatous inflammation-follicular (TF) prevalence of 7.1%, prompting azithromycin mass drug administration (MDA). After three MDA rounds (2015-2017), a trachoma impact survey was conducted in 2017. This study's aim was to estimate the prevalence of clinical signs and ocular Chlamydia trachomatis infection identified with DNA testing. A cross-sectional, cluster-random sampling design was used, and certified graders assessed participants for clinical signs and swabbed children for C. trachomatis. The TF prevalence was 6.3% (95% CI: 4.0-10.0), and C. trachomatis prevalence was 0.8% (95% CI: 0.2-3.1). Chlamydia trachomatis infection was clustered centrally in the locality within communities with high TF prevalence. Despite MDA interventions, TF remained above the established 5% elimination threshold, and C. trachomatis infection was observed. Complementary indicators, such as C. trachomatis infection, should be considered in trachoma programs as they aid in better understanding trachoma endemicity.

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沙眼流行在Al Rahad地区，苏丹：评估沙眼衣原体感染流行作为一个补充方案指标。

沙眼仍在苏丹流行。2009年Al Rahad地区基线调查显示沙眼炎症-滤泡（TF）患病率为7.1%，促使阿奇霉素大量给药（MDA）。经过三轮MDA(2015-2017)， 2017年进行了沙眼影响调查。本研究的目的是估计临床症状的患病率和眼部沙眼衣原体感染鉴定的DNA检测。采用横断面整群随机抽样设计，认证评分员评估参与者的临床症状和沙眼衣原体拭子患儿。TF患病率为6.3% (95% CI: 4.0-10.0)，沙眼衣原体患病率为0.8% （95% CI: 0.2-3.1）。沙眼衣原体感染集中聚集在高发社区内。尽管有MDA干预，但TF仍高于5%的消除阈值，并观察到沙眼衣原体感染。补充指标，如沙眼衣原体感染，应考虑在沙眼规划，因为它们有助于更好地了解沙眼地方性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Tropical Medicine and Hygiene 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.20

自引率

3.00%

发文量

508

审稿时长

3 months

期刊介绍： The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine. The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development. The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal. Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries