Four novel Co/Cu-based electrochemical sensors with pyrazole ligand for detection of uric acid, dopamine, and acetaminophen

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Transition Metal Chemistry Pub Date : 2026-05-08 DOI:10.1007/s11243-026-00738-x

Sheng Long, Wei Yao, Bang Yang, Ru Yang, Yunhui Feng, Baotong Xu, Enjun Gao, Vladimir Fedin

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引用次数: 0

Abstract

Benefits from the pyrazole ligands 4, 5-bis(pyrazole-1-yl) phthalic acid (C₁₄N₄O₄H₁₀), Co(NO)₃·6H₂O and Cu(NO)₃·3H₂O, four 3D supramolecular compounds ([Co(C₁₄N₄O₄H₉)₂(H₂O)₂]∙2H₂O (1), [Co₂(C₁₆N₄O₄H₁₃)₂(CH₃COO)₂]·C₂H₅OH (2), [Co(C₁₄N₄O₄H₉)(CH₃COO)(C₃H₇OH)]·C₃H₇OH (3)) and [Cu₂(C₁₄N₄O₄H₉)₂(H₂O)₂]∙6H₂O (4) were synthesized. Among them, the ethanol solution in compound 2 can be used as both solvent and reactant to form 4, 5-bis(pyrazole-1-yl) ethyl phthalate with 4, 5-bis (pyrazole-1-yl) phthalate (C₁₆N₄O₄H₁₄), which is directly synthesized by a one-step method. This study reports a one-step synthesis method for ester compounds, opening new avenues for the synthesis of ester compounds using solvent. Compounds 1–4 were doped with graphite to prepare a series of composite carbon paste electrodes, and their electrochemical sensing performance toward uric acid, dopamine, and acetaminophen was investigated. Among the four compounds, the modified electrode prepared using 1 and 4 exhibited excellent electrochemical sensing performance, high sensitivity, exceptional selectivity, and remarkable recyclability for detecting uric acid (pH = 7), dopamine (pH = 4) and acetaminophen (pH = 7) in PBS solution.

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四种新型Co/ cu基吡唑配体电化学传感器用于检测尿酸、多巴胺和对乙酰氨基酚

利用吡唑配体4,5 -双（吡唑-1-酰基）邻苯二甲酸（C14N4O4H10）、Co(NO)3·6H2O和Cu(NO)3·3H2O，合成了四个三维超分子化合物[Co(C14N4O4H9)2(H2O)2]∙2H2O(1)、[Co2(C16N4O4H13)2(CH3COO)2]·C2H5OH(2)、[Co(C14N4O4H9)(CH3COO)（C3H7OH)]·C3H7OH(3)）和[Cu2(C14N4O4H9)2(H2O)2]∙6H2O(4)。其中，化合物2中的乙醇溶液可作为溶剂和反应物，与4,5 -双（吡唑-1-基）邻苯二甲酸乙酯（C16N4O4H14）形成4,5 -双（吡唑-1-基）邻苯二甲酸乙酯（C16N4O4H14），直接一步合成。本研究报道了一种一步合成酯类化合物的方法，为溶剂合成酯类化合物开辟了新的途径。将化合物1 ~ 4掺杂石墨制备了一系列复合碳糊电极，研究了它们对尿酸、多巴胺和对乙酰氨基酚的电化学传感性能。其中，1和4制备的修饰电极在检测PBS溶液中的尿酸（pH = 7）、多巴胺（pH = 4）和对乙酰氨基酚（pH = 7）方面表现出优异的电化学传感性能、高灵敏度、优异的选择性和显著的可回收性。

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来源期刊

Transition Metal Chemistry 化学-无机化学与核化学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

1.3 months

期刊介绍： Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc. Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.