Socio-Occupational Functioning after Subthalamic Deep Brain Stimulation in Parkinson's Disease.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Movement Disorders Clinical Practice Pub Date : 2026-05-01 DOI:10.1002/mdc3.70661

Gabriele Imbalzano, Elisa Montanaro, Martina Giacchero, Claudia Ledda, Alberto Romagnolo, Mario Giorgio Rizzone, Leonardo Lopiano, Maurizio Zibetti

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引用次数: 0

Abstract

Background: Socio-occupational functioning in patients with Parkinson's disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) is not fully captured by standard motor and quality-of-life scales.

Objectives: To characterize patient-reported socio-occupational functioning after STN-DBS and explore associated clinical and demographic factors.

Methods: Thirty-four PD patients were assessed 9-18 months postoperatively using a semi-structured interview covering socio-occupational domains. A composite mean score (Q_mean) was computed as a descriptive index, with clinical associations explored using univariate screening and multivariate linear regression.

Results: The Q_mean score following STN-DBS was 7.66 ± 0.86 (range 6.00-9.57). In exploratory multivariate analysis, female sex (n = 7) was associated with higher functioning (P = 0.003), whereas GBA variants (n = 5) with lower functioning (P = 0.007).

Discussion: Perceived socio-occupational functioning was overall satisfactory at postoperative assessment, with limited association with conventional motor/neuropsychiatric measures, and greater association with individual factors such as sex and genetic background. These exploratory findings support inclusion of socio-occupational perspectives in DBS outcome evaluation.

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帕金森病丘脑下深部脑刺激后的社会职业功能。

背景：接受丘脑下核深部脑刺激（STN-DBS）治疗的帕金森病（PD）患者的社会职业功能未被标准运动和生活质量量表完全捕获。目的：描述STN-DBS后患者报告的社会职业功能，并探讨相关的临床和人口因素。方法：采用涵盖社会职业领域的半结构化访谈对34例PD患者进行术后9-18个月的评估。计算综合平均评分（Q_mean）作为描述性指标，并使用单因素筛选和多因素线性回归探讨临床关联。结果：STN-DBS术后Q_mean评分为7.66±0.86（范围6.00 ~ 9.57）。在探索性多变量分析中，女性（n = 7）与较高的功能相关（P = 0.003），而GBA变体（n = 5）与较低的功能相关（P = 0.007）。讨论：在术后评估中，感知到的社会职业功能总体上是令人满意的，与传统的运动/神经精神测量的关联有限，与性别和遗传背景等个人因素的关联更大。这些探索性发现支持在DBS结果评估中纳入社会职业观点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)