Comparison Between Respiratory-Triggered and Free-Breathing Signal Acquisition Methods for Single-Voxel Phosphorus Magnetic Resonance Spectroscopy of the Liver on a Clinical System.
IF 3.5 2区 医学Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Kumi Ozaki, Jihun Kwon, Marc Van Cauteren, Yasutomo Katsumata, Yukichi Tanahashi, Satoshi Goshima
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引用次数: 0
Abstract
Background: The optimal protocol for clinical liver 31P-magnetic resonance spectroscopy (MRS) remains unclear. Single-voxel 31P-MRS using image-selected in vivo spectroscopy (ISIS) employs respiratory-triggering (RT) or free-breathing (FB) acquisition. RT provides robust data but prolongs scan duration; FB allows faster acquisition but may suffer from low signal-to-noise ratio (SNR). Yet, direct comparison using a regulatory-approved coil in a clinical setting has not been reported.
Purpose: To compare 31P-MRS data stability and robustness between RT and FB.
Study type: Prospective.
Population: 24 volunteers (19 male/5 female).
Field strength/sequence: 3 T MRI; single-voxel 31P-MRS using ISIS (free induction decay-based) with approved 31P coil.
Methods: 31P-MRS was performed using RT and FB techniques (128 and 192 signal averages, respectively; expected scan duration ~13 min each). Spectra were analyzed using jMRUI. SNR and peak areas for PME, Pi, PDE, α-ATP, and NADPH, normalized using γ-ATP, were compared. PME/PDE and NADPH/(PME + PDE) ratios were also compared.
Statistical test: Paired t-tests and Bland-Altman analysis were used. A p value < 0.05 was considered significant.
Results: Scan duration was significantly longer for RT (15 min 44 s) than FB (12 min 56 s). No significant differences were observed for SNR (p = 0.570), NADPH/(PME + PDE) (p = 0.931), PME/γ-ATP (p = 0.556), Pi/γ-ATP (p = 0.931), α-ATP/γ-ATP (p = 0.332), or NADPH/γ-ATP (p = 0.394). Significant differences were noted for PDE/γ-ATP (RT 1.68 vs. FB 1.35, p = 0.003) and PME/PDE (RT 0.434 vs. FB 0.489, p = 0.046). Bland-Altman analysis showed near-zero fixed biases and no proportional bias, with limits of agreement from -0.53 to 0.62 (PME), -0.30 to 0.30 (Pi), -0.41 to 1.07 (PDE), -0.45 to 0.43 (α-ATP), and -0.80 to 0.90 (NADPH).
Data conclusion: 31P-MRS of the liver showed equivalent stability and robustness for RT and FB. FB yielded comparable data within a shorter, predictable scan duration.
期刊介绍：
The Journal of Magnetic Resonance Imaging (JMRI) is an international journal devoted to the timely publication of basic and clinical research, educational and review articles, and other information related to the diagnostic applications of magnetic resonance.
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