In utero and childhood exposure to organochlorines and perfluorinated chemicals in relation to sperm aneuploidy in adulthood.

IF 5.3 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Health Pub Date : 2026-05-02 DOI:10.1186/s12940-026-01303-w

Melissa J Perry, Alessandra Meddis, Heather A Young, C Rebecca Robbins, Esben Budtz-Jørgensen, Niels Jørgensen, Jónrit Halling, Pál Weihe, Philippe Grandjean, Maria Skaalum Petersen

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引用次数: 0

Abstract

Background: Sperm chromosomal abnormalities are linked to infertility and may be caused by endocrine disrupting chemical exposures during development.

Objectives: We examined whether exposure to organochlorine compounds (OC), including polychlorinated compounds (PCBs), and perfluorinated compounds (PFASs) measured repeatedly since birth predicted sperm chromosomal abnormalities in young adulthood.

Methods: Aneuploidy was determined in semen samples obtained from 96 Faroese young men aged 22-24 years who were members of a birth cohort created in 1986-1987. Their current and previous serum as well as cord blood were analyzed for DDE, major PCB congeners (118, 138, 153, and 180), and PFAS (PFOA, PFOS, PFNA, PFDA, and PFHxS). Incidence rate ratios between the exposures and the risk of an extra sex chromosome in adult sperm were assessed as indication of meiotic errors. The mixture effect for overall exposures (PCBs and/or PFASs) was estimated as the change in the percentage of each type of disomy for a doubling of the exposures for two individuals within the same smoking status and abstinence time group.

Results: Higher concentrations of organochlorines in cord blood and in serum at ages 7, 14 years and 22 years were associated with increased proportions of chromosomal disomies. The PCB concentration in cord blood was associated mainly with having an extra Y chromosome (p-value: 0.006), while PFAS concentrations at adulthood were consistently associated with XX18 and YY18 disomies (p-values < 0.05).

Discussion: These findings provide new evidence that fetal and subsequent chemical exposures can have enduring influence into adulthood on the formation of male germ cells.

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子宫内和儿童期接触有机氯和全氟化学品与成年期精子非整倍体的关系。

背景：精子染色体异常与不孕症有关，可能是由于发育过程中接触内分泌干扰化学物质引起的。目的：我们研究了自出生以来反复测量的有机氯化合物（OC），包括多氯化合物（PCBs）和全氟化合物（PFASs）暴露是否能预测青年期精子染色体异常。方法：对96名年龄在22-24岁的法罗年轻男性的精液样本进行非整倍体测定，这些男性是1986-1987年出生队列的成员。分析他们现在和以前的血清以及脐带血的DDE，主要的PCB同系物（118,138,153和180）和PFAS （PFOA， PFOS， PFNA， PFDA和PFHxS）。暴露与成年精子中额外性染色体风险之间的发生率比被评估为减数分裂错误的指示。总体暴露（多氯联苯和/或全氟磺酸）的混合效应被估计为在相同吸烟状态和戒烟时间的组中，两个人暴露两倍时每种类型的体格百分比的变化。结果：7岁、14岁和22岁时脐带血和血清中有机氯浓度较高与染色体畸变比例增加有关。脐带血中多氯联苯浓度主要与多一条Y染色体相关（p值：0.006），而成年期PFAS浓度始终与XX18和YY18二体症相关(p值讨论：这些发现提供了新的证据，表明胎儿和随后的化学品暴露可能对成年期男性生殖细胞的形成产生持久的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Environmental Health 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

10.10

自引率

1.70%

发文量

115

审稿时长

3.0 months

期刊介绍： Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology. Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.