Cytotoxic trichothecene derivatives from Trichothecium sp. DWS815

IF 4.9 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2026-05-03 DOI:10.1007/s13659-026-00613-3

Peng-Ju Xu, Ai-Lin Liang, Wen-Yu Lu, Hong-Ping Long, Qing-Hui Xiao, Qi-An Chen, Meng-Lan Hu, Ngoc Nhu Thao Nguyen, Shao Liu, Jing Li, Wen-Xuan Wang

{"title":"Cytotoxic trichothecene derivatives from Trichothecium sp. DWS815","authors":"Peng-Ju Xu, Ai-Lin Liang, Wen-Yu Lu, Hong-Ping Long, Qing-Hui Xiao, Qi-An Chen, Meng-Lan Hu, Ngoc Nhu Thao Nguyen, Shao Liu, Jing Li, Wen-Xuan Wang","doi":"10.1007/s13659-026-00613-3","DOIUrl":null,"url":null,"abstract":"<div><p>Ten novel trichothecene sesquiterpenoids including two new <i>seco</i>-trichothecenes, trichotheciumones A (<b>1</b>) and B (<b>2</b>), a new trichothecene sesquiterpenoid glycoside, trichothecinoside A (<b>3</b>), and seven new trichothecene sesquiterpenoids, trichothecrotocins T−Z (<b>4</b>−<b>10</b>), together with three new natural products (<b>11</b>−<b>13</b>) and thirteen known compounds (<b>14</b>−<b>26</b>), were isolated from the soil fungus <i>Trichothecium</i> sp. DWS815. The structures and absolute configurations of the new compounds were elucidated by extensive spectroscopic analyses and quantum chemistry ECD calculations. Given the notable anticancer properties of known trichothecenes, the isolated compounds were evaluated for the cytotoxic activities against three cancer cell lines (HCT116, 4T1, MHCC97H) and one normal cell line (GES-1). Cell cycle analysis revealed new compounds <b>7</b> and <b>8</b> induced G2/M phase arrest in HCT116 cancer cells, which resulted to cell proliferation inhibition activity.</p><h3>Graphical Abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture><span>The alternative text for this image may have been generated using AI.</span></div></div></figure></div></div>","PeriodicalId":718,"journal":{"name":"Natural Products and Bioprospecting","volume":"16 1","pages":""},"PeriodicalIF":4.9000,"publicationDate":"2026-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s13659-026-00613-3.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Products and Bioprospecting","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s13659-026-00613-3","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Ten novel trichothecene sesquiterpenoids including two new seco-trichothecenes, trichotheciumones A (1) and B (2), a new trichothecene sesquiterpenoid glycoside, trichothecinoside A (3), and seven new trichothecene sesquiterpenoids, trichothecrotocins T−Z (4−10), together with three new natural products (11−13) and thirteen known compounds (14−26), were isolated from the soil fungus Trichothecium sp. DWS815. The structures and absolute configurations of the new compounds were elucidated by extensive spectroscopic analyses and quantum chemistry ECD calculations. Given the notable anticancer properties of known trichothecenes, the isolated compounds were evaluated for the cytotoxic activities against three cancer cell lines (HCT116, 4T1, MHCC97H) and one normal cell line (GES-1). Cell cycle analysis revealed new compounds 7 and 8 induced G2/M phase arrest in HCT116 cancer cells, which resulted to cell proliferation inhibition activity.

Graphical Abstract

The alternative text for this image may have been generated using AI.

查看原文本刊更多论文

毛霉属的细胞毒性毛霉衍生物。

从土壤真菌Trichothecium sp. DWS815中分离得到10个新Trichothecium倍半萜类化合物，包括2个新sechotheciumones A(1)和B(2)， 1个新trichotheciumones A(3)， 7个新trichotheciumones T-Z(4-10)，以及3个新天然产物（11-13）和13个已知化合物（14-26）。通过广泛的光谱分析和量子化学ECD计算，阐明了新化合物的结构和绝对构型。考虑到已知的毛霉菌烯具有显著的抗癌特性，我们对3种癌细胞（HCT116、4T1、MHCC97H）和1种正常细胞系（GES-1）进行了细胞毒活性评价。细胞周期分析显示，新化合物7和8诱导HCT116癌细胞G2/M期阻滞，导致细胞增殖抑制活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.