Frailty, Physical Function Impairment, and Pulmonary Function in Aging Men With and Without HIV from the Multicenter AIDS Cohort Study.

IF 1.1 4区医学 Q4 IMMUNOLOGY

AIDS research and human retroviruses Pub Date : 2026-05-01 DOI:10.1177/08892229261448283

Mona Abdo, Ken M Kunisaki, Alison Morris, Valentina Stosor, Dong Chang, Gypsyamber D'Souza, Kristina Crothers, Madiha Abdel-Maksoud, Carolyn DiGuiseppi, Todd T Brown, Samantha MaWhinney, Kristine M Erlandson

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Abstract

People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairments. Associations of frailty and physical function (gait speed [m/s], grip strength [kg]) with pulmonary function (<80% predicted diffusing capacity for carbon monoxide [DL_CO] and forced expiratory volume [FEV₁]) 3 years later were modeled; age, HIV status, and smoking were assessed as effect modifiers. Among 1,024 men (54% PAWH, 10% frail, 51% prefrail), mean (SD) age = 53 (12) years, cumulative smoking = 12 (19) pack-years, gait speed = 1.1 (0.2) m/s, and grip strength = 36.6 (9.2) kg. Frailty, prefrailty, and weak grip strength were associated with higher odds of subsequent impaired DL_CO and FEV₁. Slow gait speed was associated with higher odds of DL_CO impairment but not FEV₁. No statistically significant modifications were found. Interventions to improve physical function may help preserve pulmonary function.

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多中心艾滋病队列研究中携带和不携带HIV的老年男性的虚弱、身体功能损害和肺功能

老年艾滋病毒感染者（PAWH）的身体和肺功能的损害比未感染艾滋病毒的人更大。我们检查了基线身体功能是否与随后的肺损伤有关。模拟3年后虚弱和身体功能（步速[m/s]、握力[kg]）与肺功能（CO）和用力呼气量（FEV1）的关系；年龄、HIV状态和吸烟被评估为影响因素。在1,024名男性中（54% PAWH， 10%虚弱，51%虚弱），平均（SD）年龄= 53（12）岁，累积吸烟= 12（19）包年，步态速度= 1.1 (0.2)m/s，握力= 36.6 (9.2)kg。虚弱，虚弱和握力弱与随后DLCO和FEV1受损的几率较高相关。步态速度慢与DLCO损伤的几率较高有关，但与FEV1无关。没有发现统计学上显著的变化。改善身体机能的干预措施可能有助于保护肺功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS research and human retroviruses 医学-病毒学

CiteScore

3.10

自引率

6.70%

发文量

201

审稿时长

3-6 weeks

期刊介绍： AIDS Research and Human Retroviruses was the very first AIDS publication in the field over 30 years ago, and today it is still the critical resource advancing research in retroviruses, including AIDS. The Journal provides the broadest coverage from molecular biology to clinical studies and outcomes research, focusing on developments in prevention science, novel therapeutics, and immune-restorative approaches. Cutting-edge papers on the latest progress and research advances through clinical trials and examination of targeted antiretroviral agents lead to improvements in translational medicine for optimal treatment outcomes. AIDS Research and Human Retroviruses coverage includes: HIV cure research HIV prevention science - Vaccine research - Systemic and Topical PreP Molecular and cell biology of HIV and SIV Developments in HIV pathogenesis and comorbidities Molecular biology, immunology, and epidemiology of HTLV Pharmacology of HIV therapy Social and behavioral science Rapid publication of emerging sequence information.