Principles for the design of multispecific proteins.

IF 11 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Trends in Biochemical Sciences Pub Date : 2026-05-02 DOI:10.1016/j.tibs.2026.04.007

Shankar Raj Devkota, Pramod Aryal, Mikaela Bell, Surendra Kunwar, Martin J Stone, Ram Prasad Bhusal

引用次数: 0

Abstract

Multispecificity involves high-affinity binding to multiple related ligands while preserving discrimination against other ligands. The binding of tick evasins to human CC chemokines exemplifies key principles of multispecific binding: a rigid core recognising conserved features of all targets, with flexible peripheral regions enabling discrimination within the target family.

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多特异性蛋白的设计原则。

多特异性涉及与多个相关配体的高亲和力结合，同时保留对其他配体的歧视。tick evasins与人类CC趋化因子的结合例证了多特异性结合的关键原则：刚性核心识别所有靶标的保守特征，灵活的外围区域允许在靶标家族内进行区分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in Biochemical Sciences 生物-生化与分子生物学

CiteScore

22.90

自引率

0.70%

发文量

148

审稿时长

6-12 weeks

期刊介绍： For over 40 years, Trends in Biochemical Sciences (TIBS) has been a leading publication keeping readers informed about recent advances in all areas of biochemistry and molecular biology. Through monthly, peer-reviewed issues, TIBS covers a wide range of topics, from traditional subjects like protein structure and function to emerging areas in signaling and metabolism. Articles are curated by the Editor and authored by top researchers in their fields, with a focus on moving beyond simple literature summaries to providing novel insights and perspectives. Each issue primarily features concise and timely Reviews and Opinions, supplemented by shorter articles including Spotlights, Forums, and Technology of the Month, as well as impactful pieces like Science & Society and Scientific Life articles.