Origins and drivers of self-reactive B cells in autoimmune disease

IF 3.3 4区医学 Q3 CELL BIOLOGY

Immunology & Cell Biology Pub Date : 2026-07-03 Epub Date: 2026-05-01 DOI:10.1111/imcb.70128

Adrian Y S Lee, Qian Shen, Joanne H Reed

引用次数: 0

Abstract

Self-reactive B cells are a hallmark of autoimmune disease and may directly contribute to disease pathogenesis. This Research Highlight article reviews four articles published in 2025 that offer new insights into the origins and drivers of self-reactive B cells. These studies investigate self-reactive B cells in human peripheral blood, murine models, and the role of viral and genetic drivers.

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自身免疫性疾病中自身反应性B细胞的起源和驱动因素。

自身反应性B细胞是自身免疫性疾病的标志，可能直接参与疾病的发病机制。这篇研究重点文章回顾了2025年发表的四篇文章，这些文章为自反应性B细胞的起源和驱动因素提供了新的见解。这些研究调查了人类外周血、小鼠模型中的自反应性B细胞，以及病毒和遗传驱动因素的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology & Cell Biology 医学-免疫学

CiteScore

7.50

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.