SO₂-Mediated Decarboxylative C(sp³)-C(sp³) Coupling of Carboxylic Acids Enabled by Photoredox Catalysis.

IF 3.3 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2026-05-01 DOI:10.1002/asia.70768

Jie Chen, Yuyue Qiu, Mengmeng Fu, Tao Guo, Kaicheng Xu, Ziyu Li, Fan Luo, Shihui Liu

引用次数: 0

Abstract

Herein, we report a photoredox-catalyzed, decarboxylative C(sp³)-C(sp³) coupling of carboxylic acids, facilitated by SO₂ as a key oxidant. Alkyl radicals, generated via photoredox decarboxylation, undergo homocoupling under the mild oxidizing conditions provided by SO₂. Mechanistic studies confirm that SO₂ serves a crucial role in mediating the radical cross-coupling. This work pioneers an SO₂-driven radical coupling strategy, offering a practical method for constructing C(sp³)-C(sp³) bonds and advancing synthetic applications in pharmaceutical research.

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光氧化还原催化so2介导的羧酸脱羧C(sp3)-C（sp3）偶联

在此，我们报道了光氧化催化的羧酸脱羧C(sp3)-C（sp3）偶联，SO2作为关键氧化剂促进。通过光氧化还原脱羧生成的烷基自由基在SO2提供的温和氧化条件下发生均偶联。机制研究证实SO2在介导自由基交叉偶联中起关键作用。这项工作开创了二氧化硫驱动的自由基偶联策略，为构建C(sp3)-C（sp3）键提供了实用的方法，并推进了合成在药物研究中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).

SO2-Mediated Decarboxylative C(sp3)-C(sp3) Coupling of Carboxylic Acids Enabled by Photoredox Catalysis.

Abstract

SO₂-Mediated Decarboxylative C(sp³)-C(sp³) Coupling of Carboxylic Acids Enabled by Photoredox Catalysis.