Min Wang, Linhao Wang, Ting Zhao, Yanmin Zhang, Hua Li
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引用次数: 0
Abstract
Obesity, a global health crisis driven by excessive body fat accumulation, predisposes individuals to metabolic disorders such as type 2 diabetes, cardiovascular disease, cancer, and fatty liver disease. Although genetic and environmental factors play roles in the pathogenesis of obesity, recent transcriptomic studies have revealed that noncoding RNAs (ncRNAs), particularly long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), act as key regulators of crucial pathways in obesity, including adipogenesis, inflammation, insulin resistance, and energy homeostasis. This review synthesizes emerging evidence on the roles of lncRNAs and circRNAs in obesity and its complications, emphasizing their utility as biomarkers and therapeutic targets. We further discuss challenges in translating ncRNA biology into clinical practice and propose integrative strategies to advance precision medicine for obesity.
期刊介绍：
Obesity Reviews is a monthly journal publishing reviews on all disciplines related to obesity and its comorbidities. This includes basic and behavioral sciences, clinical treatment and outcomes, epidemiology, prevention and public health. The journal should, therefore, appeal to all professionals with an interest in obesity and its comorbidities.
Review types may include systematic narrative reviews, quantitative meta-analyses and narrative reviews but all must offer new insights, critical or novel perspectives that will enhance the state of knowledge in the field.
The editorial policy is to publish high quality peer-reviewed manuscripts that provide needed new insight into all aspects of obesity and its related comorbidities while minimizing the period between submission and publication.
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