Simultaneous Determination of Residues of the Most Important Veterinary Drugs in Environmental Samples by Chromatography-Mass-Spectrometry

IF 1.5 4区化学 Q4 CHEMISTRY, ANALYTICAL

Journal of Analytical Chemistry Pub Date : 2026-05-04 DOI:10.1134/S1061934826700152

D. Yu. Nekrasov, O. I. Lavrukhina, I. V. Batov, A. V. Tret’yakov

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Abstract

A method for the determination of residues of 19 veterinary drugs (sulfonamides, coccidiostats, NSAIDs, fluoroquinolones, macrolides, lincosamides, and tetracyclines) in environmental objects using high-performance liquid chromatography with tandem mass spectrometry detection is developed. A universal sample preparation method using liquid-liquid extraction is proposed for analyzing soil, water, and plant samples. The accuracy of the analysis is ensured by the addition of isotopically labeled standards. The developed approach enables the simultaneous determination of residues of enrofloxacin, ciprofloxacin, ofloxacin, oxytetracycline, doxycycline, tetracycline, sulfamethazine, sulfamethoxazole, sulfadiazine, trimethoprim, erythromycin, clarithromycin, tylosin, tilmicosin, spiramycin, diclofenac, lasalocid, maduramicin, and lincomycin in environmental objects with minimal sample preparation. The lower limit of detection for most analytes does not exceed 5 μg/L (μg/kg). Analysis time is 30 min.

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色谱-质谱法同时测定环境样品中最重要兽药的残留

建立了高效液相色谱-串联质谱法测定环境中19种兽药（磺胺类药物、抗球虫药、非甾体抗炎药、氟喹诺酮类药物、大环内酯类药物、林科胺类药物和四环素类药物）残留的方法。提出了一种采用液液萃取的通用样品制备方法，用于分析土壤、水和植物样品。通过添加同位素标记的标准品，确保了分析的准确性。该方法可同时测定环境物体中恩诺沙星、环丙沙星、氧氟沙星、土霉素、多西环素、四环素、磺胺甲基嗪、磺胺甲恶唑、磺胺嘧啶、甲氧苄啶、红霉素、克拉霉素、泰洛星、替米科星、螺旋霉素、双氯芬酸、去沙酸、马杜洛霉素和林可霉素的残留量。大多数分析物的检测下限不超过5 μg/L （μg/kg）。分析时间为30分钟。

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来源期刊

Journal of Analytical Chemistry 化学-分析化学

CiteScore

2.10

自引率

9.10%

发文量

146

审稿时长

13 months

期刊介绍： The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.