Alleviating effects of KGC19b on periodontal inflammation through anti-inflammatory and induction of osteogenic differentiation in in vitro and in vivo experimental models

IF 5.6 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Ginseng Research Pub Date : 2026-05-01 Epub Date: 2026-02-21 DOI:10.1016/j.jgr.2026.101014

Da Eun Lee , Eun-Nam Kim , Nguyen Minh Trang , Jong Han Kim , Gi-Bang Koo , You Hee Jung , Gil-Saeng Jeong

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引用次数: 0

Abstract

Background

Panax ginseng Meyer of the Araliaceae family have various biological activities and pharmacological actions such as anticancer, immunomodulation, and anti-inflammatory. In many studies on ginseng, studies on ginseng fruit are still new, and the effect and potential of ginseng fruit on periodontitis in HPDL cells have been investigated in vitro and in vivo.

Methods

HPDL cells were stimulated with PG-LPS for 12 h to evaluate the effects of KGC19b (50–200 μg/mL) on periodontitis. Cell viability, pro-inflammatory markers, reactive oxygen species (ROS), and osteogenesis-related markers were assessed. In the rat model, periodontitis was induced using ligature and PG-LPS, and KGC19b was administered orally for 6 days. The effects of KGC19b were evaluated by micro-CT analysis and H&E staining.

Results

KGC19b reduced pro-inflammatory cytokine expression, restored osteogenic markers, enhanced antioxidant enzyme activity, and decreased ROS in HPDL cells. In the rat model, KGC19b alleviated periodontal inflammation and prevented bone mass loss.

Conclusion

In this study, KGC19b shows the possibility of improving and treating periodontitis through anti-inflammatory, osteogenesis, and antibacterial effects.

Abstract Image

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在体外和体内实验模型中，KGC19b通过抗炎和诱导成骨分化减轻牙周炎症的作用

背景五加科人参具有抗癌、免疫调节、抗炎等多种生物活性和药理作用。在众多关于人参的研究中，对人参果实的研究还处于起步阶段，人参果实对HPDL细胞牙周炎的作用和潜力已在体内和体外进行了研究。方法用PG-LPS刺激shpdl细胞12 h，观察KGC19b （50 ~ 200 μg/mL）对牙周炎的影响。评估细胞活力、促炎标志物、活性氧（ROS）和成骨相关标志物。在大鼠模型中，采用结扎法和PG-LPS诱导牙周炎，并口服KGC19b 6 d。通过显微ct分析和H&；E染色评价KGC19b的作用。结果skgc19b可降低HPDL细胞促炎因子表达，恢复成骨标志物，增强抗氧化酶活性，降低ROS水平。在大鼠模型中，KGC19b可减轻牙周炎症，防止骨量丢失。结论KGC19b具有抗炎、成骨、抗菌等作用，有改善和治疗牙周炎的可能。

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来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.