No distinct estrogenic or androgenic activity was observed in Korean Red Ginseng metabolites prepared using a S9 system

IF 7.5 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Ginseng Research Pub Date : 2026-05-01 Epub Date: 2026-01-29 DOI:10.1016/j.jgr.2026.100989

NamKyu Lee , YiSi Yang , DeYu Tian , Sun Hee Hyun , Youn Ji Lee , YoungJoo Lee

引用次数: 0

Abstract

We determined whether Korean Red Ginseng (KRG) extract and ginsenosides (Rb1, Rg1, or Rg3) have estrogen receptor-mediated or androgen receptor-mediated activities using OECD TG455/458 assays with S9 metabolic activation. They did not elicit both hormonal receptor-mediated responses. KRG extract and ginsenosides do not have male and female sex hormone-like activity.

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用S9系统制备的红参代谢物没有明显的雌激素或雄激素活性

我们使用OECD TG455/458检测S9代谢激活，确定高丽红参（KRG）提取物和人参皂苷（Rb1， Rg1或Rg3）是否具有雌激素受体介导或雄激素受体介导的活性。它们没有引起激素受体介导的两种反应。KRG提取物和人参皂苷不具有雄性和雌性激素样活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.