Natural compounds for diabetes-related wounds or ulcers therapy: Evidence from preclinical and clinical studies

IF 7.5 2区医学 Q1 CHEMISTRY, MEDICINAL

Journal of Ginseng Research Pub Date : 2026-05-01 Epub Date: 2026-02-10 DOI:10.1016/j.jgr.2026.100990

Jia Teng , Guanchi Yan , Ming Yang , Shuangyue Wang , Yuezhu Zhao , Yanyan Wang , Jia Mi

{"title":"Natural compounds for diabetes-related wounds or ulcers therapy: Evidence from preclinical and clinical studies","authors":"Jia Teng , Guanchi Yan , Ming Yang , Shuangyue Wang , Yuezhu Zhao , Yanyan Wang , Jia Mi","doi":"10.1016/j.jgr.2026.100990","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Diabetes-related wounds or ulcers are one of the complications of diabetes that can cause a variety of functional losses. Treatment of diabetic skin ulcer (DSU) focuses on alleviating foot pressure and enhancing local circulation. Despite the availability of these treatments, the number of drugs for wound application is limited. In recent years, natural compounds obtained from plants have demonstrated positive effects on DSU and have effective in preclinical and clinical studies.</div></div><div><h3>Purpose</h3><div>The objective of the study was to assess the diabetes-related wounds or ulcers of natural compounds and the potential mechanisms.</div></div><div><h3>Study design</h3><div>and Methods: The study searched PubMed database up to January 2025.</div></div><div><h3>Results</h3><div>In the review, the efficacy and safety of natural compounds in treating diabetes-related wounds or ulcers are summarized from 42 preclinical and 13 clinical studies.</div></div><div><h3>Conclusion</h3><div>Overall, these preclinical and clinical studies advocate for the use of natural compounds in diabetes-related wounds or ulcers, indicating that ursolic acid, paeoniflorin, and <em>Curcuma zedoaria</em> polysaccharide (ZWP) could be effective and well-tolerated potential medications.</div></div>","PeriodicalId":16035,"journal":{"name":"Journal of Ginseng Research","volume":"50 3","pages":"Article 100990"},"PeriodicalIF":7.5000,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Ginseng Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1226845326000163","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/10 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Diabetes-related wounds or ulcers are one of the complications of diabetes that can cause a variety of functional losses. Treatment of diabetic skin ulcer (DSU) focuses on alleviating foot pressure and enhancing local circulation. Despite the availability of these treatments, the number of drugs for wound application is limited. In recent years, natural compounds obtained from plants have demonstrated positive effects on DSU and have effective in preclinical and clinical studies.

Purpose

The objective of the study was to assess the diabetes-related wounds or ulcers of natural compounds and the potential mechanisms.

Study design

and Methods: The study searched PubMed database up to January 2025.

Results

In the review, the efficacy and safety of natural compounds in treating diabetes-related wounds or ulcers are summarized from 42 preclinical and 13 clinical studies.

Conclusion

Overall, these preclinical and clinical studies advocate for the use of natural compounds in diabetes-related wounds or ulcers, indicating that ursolic acid, paeoniflorin, and Curcuma zedoaria polysaccharide (ZWP) could be effective and well-tolerated potential medications.

Abstract Image

查看原文本刊更多论文

用于糖尿病相关伤口或溃疡治疗的天然化合物：来自临床前和临床研究的证据

背景：糖尿病相关伤口或溃疡是糖尿病的并发症之一，可导致多种功能丧失。糖尿病性皮肤溃疡（DSU）的治疗重点是减轻足部压力和促进局部循环。尽管有这些治疗方法，但用于伤口应用的药物数量有限。近年来，从植物中提取的天然化合物对DSU有积极的作用，并在临床前和临床研究中取得了良好的效果。目的探讨天然化合物对糖尿病相关创面或溃疡的影响及其可能的机制。研究设计和方法：本研究检索PubMed数据库至2025年1月。结果综述了42项临床前研究和13项临床研究中天然化合物治疗糖尿病相关创面溃疡的疗效和安全性。结论总体而言，这些临床前和临床研究支持使用天然化合物治疗糖尿病相关伤口或溃疡，表明熊果酸、芍药苷和莪术多糖（ZWP）可能是有效且耐受性良好的潜在药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Ginseng Research CHEMISTRY, MEDICINAL-INTEGRATIVE & COMPLEMENTARY MEDICINE

CiteScore

11.40

自引率

9.50%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Journal of Ginseng Research (JGR) is an official, open access journal of the Korean Society of Ginseng and is the only international journal publishing scholarly reports on ginseng research in the world. The journal is a bimonthly peer-reviewed publication featuring high-quality studies related to basic, pre-clinical, and clinical researches on ginseng to reflect recent progresses in ginseng research. JGR publishes papers, either experimental or theoretical, that advance our understanding of ginseng science, including plant sciences, biology, chemistry, pharmacology, toxicology, pharmacokinetics, veterinary medicine, biochemistry, manufacture, and clinical study of ginseng since 1976. It also includes the new paradigm of integrative research, covering alternative medicinal approaches. Article types considered for publication include review articles, original research articles, and brief reports. JGR helps researchers to understand mechanisms for traditional efficacy of ginseng and to put their clinical evidence together. It provides balanced information on basic science and clinical applications to researchers, manufacturers, practitioners, teachers, scholars, and medical doctors.