YY1 in hematopoietic stem cells: epigenetic regulation, chromatin architecture, and aging.

IF 2.9 3区医学 Q2 HEMATOLOGY

Current Opinion in Hematology Pub Date : 2026-07-01 Epub Date: 2026-05-18 DOI:10.1097/MOH.0000000000000925

Yinghua Wang, Xuan Pan

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引用次数: 0

Abstract

Purpose of review: Yin Yang 1 (YY1) is a multifunctional transcription factor (TF) with established roles in lymphocyte development. More recently, its functions as a Polycomb group (PcG) protein and chromatin structural regulator in the hematopoietic system have gained increasing attention. This mini-review summarizes emerging insights into the epigenetic and architectural roles of YY1 in fetal and adult hematopoietic stem cells (HSCs), extending beyond its classical transcriptional activity. We also discuss how altered YY1 function contributes to HSC aging and hematopoietic decline.

Recent findings: Recent studies show that YY1 is essential for maintaining HSC quiescence, self-renewal, and engraftment during both fetal and adult hematopoiesis. Mechanistically, YY1 regulates hematopoiesis through PcG-dependent pathways and by shaping higher-order chromatin organization. It mediates long-range chromatin interactions, cooperates with cohesin and CTCF to organize three-dimensional genome architecture, and coordinates transcriptional and metabolic programs critical for stem cell maintenance. Notably, age-associated reductions in YY1 activity are linked to functional impairment of HSCs, implicating YY1 in hematopoietic aging.

Summary: YY1 acts as a TF, chromatin organizer, and PcG protein in hematopoiesis. Defining its roles in normal and aging HSCs may reveal mechanisms of hematopoietic decline and inform strategies to preserve blood system function.

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YY1在造血干细胞中的作用：表观遗传调控、染色质结构和衰老。

综述目的：阴阳1 （YY1）是一种多功能转录因子（TF），在淋巴细胞发育中具有明确的作用。近年来，它在造血系统中作为Polycomb group （PcG）蛋白和染色质结构调节剂的功能得到了越来越多的关注。这篇迷你综述总结了YY1在胎儿和成人造血干细胞（hsc）中的表观遗传和结构作用的新见解，超出了其经典的转录活性。我们还讨论了YY1功能的改变如何导致HSC老化和造血功能下降。最近的发现：最近的研究表明，YY1在胎儿和成人造血过程中维持HSC的静止、自我更新和植入是必不可少的。在机制上，YY1通过pcg依赖途径和塑造高阶染色质组织来调节造血。它介导远程染色质相互作用，与内聚蛋白和CTCF合作组织三维基因组结构，并协调对干细胞维持至关重要的转录和代谢程序。值得注意的是，年龄相关的YY1活性降低与造血干细胞的功能损伤有关，这意味着YY1与造血衰老有关。摘要：YY1在造血过程中起TF、染色质组织者和PcG蛋白的作用。确定其在正常和衰老造血干细胞中的作用可能揭示造血功能下降的机制，并为保护血液系统功能提供策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Hematology 医学-血液学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.