Proteasome-haem-BACH2 axis fuels T cell exhaustion.

IF 13.9 1区医学 Q1 IMMUNOLOGY

Trends in Immunology Pub Date : 2026-04-23 DOI:10.1016/j.it.2026.04.002

Jiajia Wang, Ziyi Luo, Haitao Shen, Lianjun Zhang

引用次数: 0

Abstract

It remains unclear how mitochondrial stress instructs the transcriptional programme of terminal T cell exhaustion. In a recent study, Xu et al. uncovered a proteasome-haem-BACH2 axis in which haem liberated from damaged mitochondrial haemoproteins acts as a molecular messenger that couples mitochondrial injury to terminal T cell exhaustion.

查看原文本刊更多论文

蛋白酶体-血- bach2轴促进T细胞衰竭。

目前尚不清楚线粒体应激如何指导终端T细胞衰竭的转录程序。在最近的一项研究中，Xu等人发现了一个蛋白酶体-血红素- bach2轴，其中从受损的线粒体血红蛋白中释放的血红素作为分子信使，将线粒体损伤与终端T细胞衰竭结合起来。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Trends in Immunology 医学-免疫学

CiteScore

25.10

自引率

0.60%

发文量

130

审稿时长

6-12 weeks

期刊介绍： Trends in Immunology serves as a vital platform for tracking advancements across various areas of immunology, offering concise reviews and hypothesis-driven viewpoints in each issue. With additional sections providing comprehensive coverage, the journal offers a holistic view of immunology. This broad perspective makes it an invaluable resource for researchers, educators, and students, facilitating the connection between basic and clinical immunology. Recognized as one of the top monthly review journals in its field, Trends in Immunology is highly regarded by the scientific community.