The Role of Adipose Tissue-Derived Stem Cells together with Vitamin C on Survival of Rats with Acute Radiation Syndrome.

Q3 Medicine

Journal of Biomedical Physics and Engineering Pub Date : 2026-04-01 DOI:10.31661/jbpe.v0i0.2310-1680

Seyed Mohammad Javad Mortazavi, Fatemeh Kadivar, Shahrokh Zare, Abolfazl Kanani, Mohammad Amin Mosleh-Shirazi, Sadegh Masoudi, Feridoun Karimi-Busheri, Davood Mehrabani

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引用次数: 0

Abstract

Background: Following any injury in radiation accidents, such as Acute Radiation Syndrome (ARS), medical interventions are recommended based on radiation dose and physiological response. Clinical management encompasses blood transfusion, hematopoietic cytokines, and stem-cell transplantation.

Objective: This study aimed to determine the effect of adipose tissue-derived stem cells (AdSCs) together with vitamin C on the survival of rats with ARS.

Material and methods: In this experimental study, 45 rats were randomly divided into 3 equal groups of animals administered with a single dose of oral 400 mg/kg vitamin C; those injected intravenously with 1.5×10⁵ AdSCs; and rats transplanted intravenously with 1.5×10⁵ AdSCs together with a single oral dose of 400 mg/kg vitamin C. All rats were already irradiated with 10 Gy (dose rate 0.286 Gy/ min) ⁶⁰CO, for 35 minutes with a field size of 35 cm × 35 cm for all body areas.

Results: A significant increase in survival rate was visible one month after γ irradiation in 73.3% of animals received AdSCs+vitamin C, 60% of rats injected with just AdSCs, and 13.3% of the group received just vitamin C.

Conclusion: Our findings revealed significant efficacy of a combined approach involving AdSC transplantation and vitamin C to enhance the survival rate following lethal irradiation. This combination could offer a potential avenue for addressing the alleviation of tissue damage caused by chemotherapy and toxic drugs. We recommend the administration of AdSCs together with vitamin C as an effective and prompt treatment option for irradiation injuries.

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脂肪组织源性干细胞与维生素C对急性放射综合征大鼠生存的作用。

背景：辐射事故损伤后，如急性辐射综合征（ARS），建议根据辐射剂量和生理反应进行医疗干预。临床管理包括输血、造血细胞因子和干细胞移植。目的：探讨脂肪组织源性干细胞（AdSCs）联合维生素C对急性呼吸道综合征大鼠存活的影响。材料与方法：将45只大鼠随机分为3组，每组均给予单次口服400 mg/kg维生素C；静脉注射1.5×105 AdSCs组；所有大鼠均已接受10 Gy（剂量率0.286 Gy/ min） 60CO照射，照射时间为35分钟，所有身体部位的照射场大小为35 cm × 35 cm。结果：73.3%的动物接受AdSCs+维生素C， 60%的大鼠只注射AdSCs， 13.3%的大鼠只注射维生素C，在γ照射后一个月存活率显著提高。结论：我们的研究结果表明，AdSC移植和维生素C联合治疗可以显著提高致死照射后的存活率。这种组合可以为缓解化疗和有毒药物引起的组织损伤提供潜在的途径。我们建议将AdSCs与维生素C联合使用，作为辐照损伤的有效和及时的治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Biomedical Physics and Engineering Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Biomedical Physics and Engineering (JBPE) is a bimonthly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research (experimental or theoretical) broadly concerned with the relationship of physics to medicine and engineering.