LncRNA PCAT18: Roles and Mechanisms in Human Cancers.

IF 4.8 2区生物学 Q1 CELL BIOLOGY

Wiley Interdisciplinary Reviews: RNA Pub Date : 2026-03-01 DOI:10.1002/wrna.70041

Xiaohui Wang, Henan Zhang, Fang Chen, Xujian Jiang, Qiang Zhang, Jihong Zhang

引用次数: 0

Abstract

lncRNAs are a group of RNA molecules with over 200 nucleotides involved in many biological processes. The dysregulation of lncRNA has been covered in several processes related to carcinogenesis, such as proliferation, apoptosis, invasion, evasion, and metastasis of cancer cells. PCAT18 is a newly discovered non-coding RNA first described as an androgen-regulated gene and highly upregulated in PCa. Recent studies revealed that PCAT18 functions as a regulatory molecule in PCa, lung cancer, breast cancer, digestive cancer, and leukemia. With this, we review the molecular mechanism and clinical significance of PCAT18 in various cancers. This article is categorized under: RNA in Disease and Development > RNA in Disease.

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LncRNA PCAT18：在人类癌症中的作用和机制

lncRNAs是一组具有200多个核苷酸的RNA分子，参与许多生物过程。lncRNA的失调已经涉及到与癌症发生相关的几个过程，如癌细胞的增殖、凋亡、侵袭、逃避和转移。PCAT18是一种新发现的非编码RNA，首次被描述为雄激素调控基因，在PCa中高度上调。近年来的研究表明，PCAT18在前列腺癌、肺癌、乳腺癌、消化系统癌和白血病中发挥调控分子的作用。为此，我们就PCAT18在各种癌症中的分子机制及临床意义进行综述。本文分类如下：RNA在疾病和发展> RNA在疾病。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Wiley Interdisciplinary Reviews: RNA CELL BIOLOGY-

CiteScore

14.80

自引率

4.10%

发文量

审稿时长

6-12 weeks

期刊介绍： WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.