The influence of elevated body mass index on protein expression in pediatric b-cell acute lymphoblastic leukemia.

IF 1.2 4区医学 Q4 HEMATOLOGY

Pediatric Hematology and Oncology Pub Date : 2026-04-28 DOI:10.1080/08880018.2026.2661067

Rachel S Werk, Jeremy M Chacón, Lucie M Turcotte, Justin R Ryder

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Abstract

This study explored protein expression in B-cell acute lymphoblastic leukemia (B-ALL) patients with and without elevated weight or obesity and controls to understand global proteomic differences between newly diagnosed B-ALL patients and controls as well as the influences of elevated body mass index (BMI) on pretreatment inflammatory and immune-related protein expression in B-ALL patients.   Protein expression was measured in serum samples of pediatric patients (aged 1-21 years) with newly diagnosed B-ALL (n = 39), and age and sex-matched controls (n = 41) using OLink panels. We examined normalized protein expression data clustered by patient information in -unsupervised hierarchical clustering and principal component analysis. Of 239 assays, 128 assays differed significantly based on B-ALL diagnosis and 4 assays (APLP1, CDHR5, GHRL, SEZ6L) varied significantly as a function of BMI. In healthy individuals, oncology marker furin (p.adjust = 0.016) was more highly expressed in the high-BMI category; this trend was reversed for B-ALL individuals. Furin expression is often upregulated in malignancies and obesity; however this suggests its expression may follow unique patterns in pediatric B- ALL patients with elevated BMI.

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体重指数升高对儿童b细胞急性淋巴细胞白血病蛋白表达的影响。

本研究探讨了b细胞急性淋巴细胞白血病（B-ALL）患者和对照组中体重或肥胖升高和未肥胖升高的蛋白质表达，以了解新诊断B-ALL患者和对照组之间的整体蛋白质组学差异，以及体重指数（BMI）升高对B-ALL患者预处理炎症和免疫相关蛋白表达的影响。 使用OLink面板测量新诊断B-ALL的儿科患者（年龄1-21岁）（n = 39）和年龄和性别匹配的对照组（n = 41）的血清样本中的蛋白表达。我们在无监督分层聚类和主成分分析中检查了规范化的蛋白质表达数据。239项检测中，128项检测基于B-ALL诊断存在显著差异，4项检测（APLP1、CDHR5、GHRL、SEZ6L）随BMI的变化存在显著差异。在健康人群中，肿瘤标志物furin （p.adjust = 0.016）在高bmi人群中表达更高；这一趋势在B-ALL个体中是相反的。在恶性肿瘤和肥胖中，Furin的表达经常上调；然而，这表明它的表达可能在BMI升高的儿童B- ALL患者中具有独特的模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Hematology and Oncology 医学-小儿科

CiteScore

2.60

自引率

5.90%

发文量

审稿时长

6-12 weeks

期刊介绍： PHO: Pediatric Hematology and Oncology covers all aspects of research and patient management within the area of blood disorders and malignant diseases of childhood. Our goal is to make PHO: Pediatric Hematology and Oncology the premier journal for the international community of clinicians and scientists who together aim to define optimal therapeutic strategies for children and young adults with cancer and blood disorders. The journal supports articles that address research in diverse clinical settings, exceptional case studies/series that add novel insights into pathogenesis and/or clinical care, and reviews highlighting discoveries and challenges emerging from consortia and conferences. Clinical studies as well as basic and translational research reports regarding cancer pathogenesis, genetics, molecular diagnostics, pharmacology, stem cells, molecular targeting, cellular and immune therapies and transplantation are of interest. Papers with a focus on supportive care, late effects and on related ethical, legal, psychological, social, cultural, or historical aspects of these fields are also appreciated. Reviews on important developments in the field are welcome. Articles from scientists and clinicians across the international community of Pediatric Hematology and Oncology are considered for publication. The journal is not dependent on or connected with any organization or society. All submissions undergo rigorous peer review prior to publication. Our Editorial Board includes experts in Pediatric Hematology and Oncology representing a wide range of academic and geographic diversity.