Epidemiological and molecular analysis of the Chikungunya virus outbreak in the state of Rondônia.

IF 3.6 2区医学 Q1 INFECTIOUS DISEASES

Infection Pub Date : 2026-04-24 DOI:10.1007/s15010-026-02773-3

Karolaine Santos Teixeira, Tárcio Peixoto Roca, Ana Maisa Passos-Silva, Edilene Pereira Pimentel, Jackson Alves da Silva Queiroz, Lourdes Maria Pinheiro Borzacov, Jansen Fernandes Medeiros, Juan Miguel Villalobos Salcedo, Deusilene Vieira

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引用次数: 0

Abstract

Purpose: The Chikungunya virus (CHIKV) is an arbovirus transmitted by hematophagous arthropods, widely distributed in tropical and subtropical regionsAQ1. In Brazil, its introduction in 2014 marked the beginning of a significant expansion, becoming a major public health problem.

Methods: This work consists of a cross-sectional study conducted from October 2024 to July 2025, in which 830 samples from patients with acute febrile illness and negative diagnosis for malaria were evaluatedAQ2. The samples were tested for dengue, Zika, and chikungunya and subjected to duplex RT-qPCR to detect Mayaro and Oropouche.

Results: Of the samples analyzed, 5,18% (43/830) tested positive for some arbovirus investigated in this cohort, of which 53,49% (23/43) were detectable for CHIKV. The phylogenetic analysis showed that all samples belonged to the East/Central/South African (ECSA) genotype, demonstrating its circulation in the region.

Conclusions: The findings reinforce the need for continuous molecular surveillance to monitor the circulation of medically important arboviruses in the Amazon region.

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Rondônia州基孔肯雅病毒暴发的流行病学和分子分析。

目的：基孔肯雅病毒（CHIKV）是一种由食血节肢动物传播的虫媒病毒，广泛分布于热带和亚热带地区。在巴西，2014年的引入标志着大规模扩张的开始，成为一个重大的公共卫生问题。方法：采用横断面研究方法，于2024年10月至2025年7月对830例疟疾诊断阴性的急性发热性疾病患者进行aq2评价。对样本进行登革热、寨卡病毒和基孔肯雅热检测，并采用双相RT-qPCR检测马雅罗病毒和奥罗普切病毒。结果：在所分析的样本中，5.18%（43/830）的虫媒病毒检测呈阳性，其中53.49%（23/43）的虫媒病毒检测呈阳性。系统发育分析表明，所有样本均属于东/中/南非（ECSA）基因型，表明其在该地区流行。结论：这些发现加强了持续分子监测的必要性，以监测亚马逊地区医学上重要的虫媒病毒的传播。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infection 医学-传染病学

CiteScore

12.50

自引率

1.30%

发文量

224

审稿时长

6-12 weeks

期刊介绍： Infection is a journal dedicated to serving as a global forum for the presentation and discussion of clinically relevant information on infectious diseases. Its primary goal is to engage readers and contributors from various regions around the world in the exchange of knowledge about the etiology, pathogenesis, diagnosis, and treatment of infectious diseases, both in outpatient and inpatient settings. The journal covers a wide range of topics, including: Etiology: The study of the causes of infectious diseases. Pathogenesis: The process by which an infectious agent causes disease. Diagnosis: The methods and techniques used to identify infectious diseases. Treatment: The medical interventions and strategies employed to treat infectious diseases. Public Health: Issues of local, regional, or international significance related to infectious diseases, including prevention, control, and management strategies. Hospital Epidemiology: The study of the spread of infectious diseases within healthcare settings and the measures to prevent nosocomial infections. In addition to these, Infection also includes a specialized "Images" section, which focuses on high-quality visual content, such as images, photographs, and microscopic slides, accompanied by brief abstracts. This section is designed to highlight the clinical and diagnostic value of visual aids in the field of infectious diseases, as many conditions present with characteristic clinical signs that can be diagnosed through inspection, and imaging and microscopy are crucial for accurate diagnosis. The journal's comprehensive approach ensures that it remains a valuable resource for healthcare professionals and researchers in the field of infectious diseases.