Integrative analysis of corticotrophs and folliculostellate cells: aging and paracrine regulation.

IF 1.4 4区医学 Q3 ANATOMY & MORPHOLOGY

Folia morphologica Pub Date : 2026-01-01 DOI:10.5603/fm.111468

Miljana N Pavlovic, Vesna R Stojanović, Milena M Trandafilović, Jovana R Čukuranović Kokoris, Vladimir S Živković, Milorad M Antić, Vladimir M Antić

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引用次数: 0

Abstract

Background: Aging of the human anterior pituitary is accompanied by structural remodeling of hormone-producing and non-endocrine cellular components. The coordinated morphometric relationship between adrenocorticotropic hormone (ACTH)-producing corticotrophs and folliculostellate (FS) cells during aging remains insufficiently characterized.

Materials and methods: Twenty-nine human anterior pituitaries (33-95 years, both sexes) obtained at autopsy were examined using immunohistochemistry for ACTH and S-100 protein. Volume densities (VVACTH, VVFS) were quantified using calibrated digital morphometry. Correlation and regression analyses were performed to assess intercellular associations and age-related trends.

Results: Both ACTH and FS cell volume densities demonstrated significant age-related increases (p < 0.05). A strong positive correlation was observed between VVACTH and VVFS (R = 0.61, p < 0.001). Regression analysis confirmed that increased FS cell density was significantly associated with increased corticotroph volume fraction.

Conclusions: Aging of the human anterior pituitary is characterized by coordinated expansion of corticotroph and FS cell compartments. These findings support structural coupling between endocrine and non-endocrine cellular networks and reinforce the concept of paracrine integration within the aging adenohypophysis.

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促皮质细胞和卵泡星状细胞的综合分析：衰老和旁分泌调节。

背景：人类垂体前叶的衰老伴随着产生激素和非内分泌细胞成分的结构重塑。促肾上腺皮质激素（ACTH）生成的促肾上腺皮质激素和卵泡星状细胞（FS）在衰老过程中的协调形态测量关系仍未充分表征。材料和方法：采用免疫组织化学方法对尸检获得的29例人垂体前叶（33-95岁，男女）进行ACTH和S-100蛋白检测。体积密度（VVACTH， VVFS）使用校准的数字形态测定法进行量化。进行相关和回归分析以评估细胞间关联和年龄相关趋势。结果：ACTH和FS细胞体积密度均与年龄相关（p < 0.05）。VVACTH与VVFS呈正相关（R = 0.61, p < 0.001）。回归分析证实FS细胞密度的增加与皮质细胞体积分数的增加显著相关。结论：人垂体前叶的衰老以促皮质细胞室和FS细胞室的协调扩张为特征。这些发现支持了内分泌和非内分泌细胞网络之间的结构耦合，并强化了衰老性腺垂体中旁分泌整合的概念。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Folia morphologica ANATOMY & MORPHOLOGY-

CiteScore

2.40

自引率

0.00%

发文量

218

审稿时长

6-12 weeks

期刊介绍： "Folia Morphologica" is an official journal of the Polish Anatomical Society (a Constituent Member of European Federation for Experimental Morphology - EFEM). It contains original articles and reviews on morphology in the broadest sense (descriptive, experimental, and methodological). Papers dealing with practical application of morphological research to clinical problems may also be considered. Full-length papers as well as short research notes can be submitted. Descriptive papers dealing with non-mammals, cannot be accepted for publication with some exception.