Laura Orsolini, Giulio Longo, Michele Giordano, Umberto Volpe
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引用次数: 0
Abstract
Major depressive disorder (MDD) is increasingly considered as a multifactorial neuropsychiatric disease involving dysregulation over multiple neurotransmitter systems. This chapter examines the complex role of serotonin, dopamine, and glutamate receptors in the pathophysiology of MDD, with a focus on their contributions to emotional regulation, reward processing, and synaptic plasticity. Recent evidence from pharmacological, genetic, and neuroimaging studies highlighted the involvement of receptor subtypes-such as 5-HT1A, 5-HT1A/C, D1-D3, and both ionotropic and metabotropic glutamate receptors-in mediating depressive symptoms and therapeutic responses. This chapter will point out potential targets for innovative and rapid-acting antidepressant strategies, emphasizing the need for personalized treatment approaches in MDD.
期刊介绍：
Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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