TPS 2.0-Based Voided Urine Cytology from Patients with Pathologically Proven Low-Grade Urothelial Carcinoma: Comparison with TPS 1.0 and JRSUC 2015.

IF 1.5 4区医学 Q3 PATHOLOGY

Acta Cytologica Pub Date : 2026-04-28 DOI:10.1159/000552295

Toshihiko Kato, Yumiko Higuchi, Mei Oshima, Fuki Endo, Tomonari Toyama, Shiro Sugihara, Sotaro Kayano, Yasuo Imai

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引用次数: 0

Abstract

Introduction: The Paris System (TPS) 1.0 for reporting urinary cytology focused on high-grade urothelial carcinoma (HGUC) but included low-grade urothelial neoplasm (LGUN) category by evaluating cell clusters. The 2015 Japan Reporting System for Urinary Cytology (JRSUC 2015) also includes low-grade urothelial carcinoma (LGUC) category. Then, TPS 2.0 deleted the LGUN category and completely focused on HGUC detection by evaluating only individual cells. We aimed to investigate this impact from the perspective of pathologically proven LGUC diagnosis.

Methods: Voided urine samples, suspected of new-onset bladder cancer, with corresponding pathological diagnosis within 3 months of cytological diagnosis were analyzed. TPS 2.0-based cytology was statistically compared with TPS 1.0- and JRSUC 2015-based ones.

Results: 189 cases, consisting of 27 pathologically proven benign lesions, 63 LGUC, 96 HGUC, and 3 other malignancies were analyzed. Cytological diagnosis demonstrated high correlation between TPS 2.0 and JRSUC 2015 (r = 0.972, p < 0.001) and complete coincidence between TPS 2.0 and TPS 1.0 (r = 1.00, p < 0.001). One and none of 63 pathological LGUC was classified as cytological LGUC/LGUN by JRSUC 2015 and TPS 1.0, respectively, validating restricted utility of the LGUC/LGUN category. Cytological diagnosis of pathological LGUC was almost consistent across three reporting systems. These systems demonstrated similar concordance levels with pathological diagnosis (TPS 1.0 and 2.0: both r = 0.483, p < 0.001; JRSUC 2015: r = 0.484, p < 0.001).

Conclusion: Even from the perspective of LGUC, TPS 2.0 would not be disadvantageous and is an excellent reporting system because of objectivity and simplicity.

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基于TPS 2.0的低级别尿路上皮癌患者空尿细胞学：与TPS 1.0和JRSUC 2015的比较

背景：Paris系统（TPS） 1.0报告的泌尿细胞学主要集中于高级别尿路上皮癌（HGUC），但通过评估细胞簇包括低级别尿路上皮肿瘤（LGUN）类别。2015年日本尿细胞学报告系统（JRSUC 2015）也包括低级别尿路上皮癌（LGUC）类别。然后，TPS 2.0删除了LGUN类别，完全专注于仅评估单个细胞的HGUC检测。我们的目的是从病理证实的LGUC诊断的角度来研究这种影响。方法：对疑似新发膀胱癌的空尿标本，在细胞学诊断后3个月内进行相应病理诊断进行分析。将基于TPS 2.0的细胞学与基于TPS 1.0和JRSUC 2015的细胞学进行统计学比较。结果：189例，病理证实为良性病变27例，LGUC 63例，HGUC 96例，其他恶性肿瘤3例。细胞学诊断显示TPS 2.0与JRSUC 2015高度相关（r = 0.96, p < 0.001）， TPS 2.0与TPS 1.0完全吻合（r = 1.00, p < 0.001）。63例病理性LGUC中分别有1例和1例被JRSUC 2015和TPS 1.0分类为细胞学LGUC/LGUN，验证了LGUC/LGUN分类的局限性。病理性LGUC的细胞学诊断在三个报告系统中几乎相同。这些系统与病理诊断的一致性水平相似（TPS 1.0和2.0:r = 0.483, p < 0.001; JRSUC 2015: r = 0.484, p < 0.001）。结论：即使从LGUC的角度来看，TPS 2.0也不会是不利的，因为它客观、简单，是一个优秀的报告系统。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Cytologica 生物-病理学

CiteScore

3.70

自引率

11.10%

发文量

审稿时长

4-8 weeks

期刊介绍： With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.