Relative Skeletal Muscle Mass Is Associated With Hepatic Steatosis in Adolescents With Overweight and Obesity.

IF 2.5 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2026-04-01 DOI:10.1111/ijpo.70108

Julia M Boster, Melanie G Cree, Megan M Kelsey, Kristen J Nadeau, Alexander Chaidez, Zhaoxing Pan, Shikha S Sundaram

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引用次数: 0

Abstract

Objectives: To assess for myopenia in adolescents with overweight/obesity (OO), and to evaluate relationships between skeletal muscle mass, hepatic steatosis and insulin sensitivity/glycemia.

Study design: Secondary analysis of data collected across seven metabolic studies in adolescents with BMI ranging from OO to healthy weight (HW). Appendicular lean mass (ALM) was measured from previously obtained dual energy x-ray absorptiometry (DXA) scans and used to calculate ALM index (ALM (kg)/weight (kg) × 100). Metabolic outcomes included MRI-based fat distribution (hepatic fat fraction [HFF], visceral and subcutaneous fat mass), fasting and glucose-stimulated laboratory assessments of insulin sensitivity, secretion, and glycemia, as obtained in the parent studies. The relationships between ALM index and metabolic outcomes were studied using multivariable linear regression.

Results: ALM was calculated in 304 adolescents-228 with OO (mean age 15.2 ± 2.4 years, Tanner stage 4.5 ± 1.1, 88.2% female) and 76 HW (13.7 ± 2.6 years, Tanner stage 3.4 ± 1.2, 59.2% female). Mean ALM index was significantly lower in OO than HW (23.7% ± 2.9% vs. 31.8% ± 4.5%, p < 0.01). ALM index had a significant association with square-root-transformed HFF (β = -0.09, SE = 0.03, t-value = -2.92, p < 0.01). ALM index was negatively associated with fasting C-peptide (p < 0.01) but not with other markers of insulin sensitivity/glycemia.

Conclusion: Low ALM index had a significant association with hepatic steatosis in adolescents with OO, bringing attention to the interplay between muscle mass and hepatic steatosis in this population. This finding has potential implications for optimal management of metabolic dysfunction-associated steatotic liver disease (MASLD), while the relationship between muscle mass and insulin sensitivity/glycemia requires further attention.

Trail registration: ClinicalTrials.gov identifiers: NCT03717935 (https://clinicaltrials.gov/study/NCT03717935), NCT03041129 (https://clinicaltrials.gov/study/NCT03041129), NCT02157974 (https://clinicaltrials.gov/study/NCT02157974), NCT01775813 (https://clinicaltrials.gov/study/NCT01775813) and NCT03919929 (https://clinicaltrials.gov/study/NCT03919929).

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相对骨骼肌质量与超重和肥胖青少年肝脂肪变性相关

目的：评估超重/肥胖（OO）青少年的肌减少症，并评估骨骼肌质量、肝脂肪变性和胰岛素敏感性/血糖之间的关系。研究设计：对BMI从0到健康体重（HW）的青少年进行的7项代谢研究收集的数据进行二次分析。通过先前获得的双能x线吸收仪（DXA）扫描测量阑尾瘦质量（ALM），并用于计算ALM指数(ALM （kg)/体重（kg） × 100）。代谢结果包括基于mri的脂肪分布（肝脏脂肪分数[HFF]，内脏和皮下脂肪块），空腹和葡萄糖刺激的胰岛素敏感性，分泌和血糖的实验室评估，如在母体研究中获得的。采用多变量线性回归研究ALM指数与代谢结局的关系。结果：304例青少年中有228例（平均年龄15.2±2.4岁，Tanner分期为4.5±1.1，女性占88.2%）；76例HW（13.7±2.6岁，Tanner分期为3.4±1.2，女性占59.2%）。肥胖青少年的平均ALM指数显著低于肥胖青少年（23.7%±2.9% vs. 31.8%±4.5%）。结论：肥胖青少年的低ALM指数与肝脂肪变性有显著的相关性，值得关注该人群中肌肉质量与肝脂肪变性之间的相互作用。这一发现对代谢功能障碍相关脂肪变性肝病（MASLD）的最佳管理具有潜在意义，而肌肉质量与胰岛素敏感性/血糖之间的关系需要进一步关注。临床试验注册：ClinicalTrials.gov标识符：NCT03717935 （https://clinicaltrials.gov/study/NCT03717935）、NCT03041129 （https://clinicaltrials.gov/study/NCT03041129）、NCT02157974 （https://clinicaltrials.gov/study/NCT02157974）、NCT01775813 （https://clinicaltrials.gov/study/NCT01775813）和NCT03919929 （https://clinicaltrials.gov/study/NCT03919929）。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.