From transcription to biological translation: regulation and recognition of MR1

IF 3.3 4区医学 Q3 CELL BIOLOGY

Immunology & Cell Biology Pub Date : 2026-07-03 Epub Date: 2026-04-23 DOI:10.1111/imcb.70125

Timothy Patton, Adam G Nelson, Alexandra J Corbett

引用次数: 0

Abstract

The axis of MR1 restricted T-cell immunity has been an area of growing interest over the past decade. In this “Highlights of 2025” perspective, we discuss recent advances in our understanding of the transcriptional regulation of MR1, the distribution of MR1 protein across tissues and the elucidation of novel MR1 ligands. The advances of 2025 have unlocked new methodologies and mechanistic insights, aiding future studies that consider MR1 and its contribution to the development of MR1-restricted T-cell responses in the context of infection, cancer and autoimmunity.

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从转录到生物翻译：MR1的调控和识别。

在过去的十年中，MR1限制t细胞免疫的轴一直是一个越来越受关注的领域。在这篇“2025年的亮点”展望中，我们讨论了MR1转录调控的最新进展，MR1蛋白在组织中的分布以及新型MR1配体的阐明。2025年的进展揭示了新的方法和机制见解，有助于未来研究考虑MR1及其在感染、癌症和自身免疫背景下对MR1限制性t细胞反应发展的贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunology & Cell Biology 医学-免疫学

CiteScore

7.50

自引率

2.50%

发文量

审稿时长

4-8 weeks

期刊介绍： The Australasian Society for Immunology Incorporated (ASI) was created by the amalgamation in 1991 of the Australian Society for Immunology, formed in 1970, and the New Zealand Society for Immunology, formed in 1975. The aim of the Society is to encourage and support the discipline of immunology in the Australasian region. It is a broadly based Society, embracing clinical and experimental, cellular and molecular immunology in humans and animals. The Society provides a network for the exchange of information and for collaboration within Australia, New Zealand and overseas. ASI members have been prominent in advancing biological and medical research worldwide. We seek to encourage the study of immunology in Australia and New Zealand and are active in introducing young scientists to the discipline.