Ficus carica Extract Loaded 3D-Printed Sodium Alginate/Guar Gum Scaffolds for Potential Wound Healing Applications: An In Vitro Study.

IF 2.8 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

ChemBioChem Pub Date : 2026-04-28 DOI:10.1002/cbic.202500875

Aima Ghouri, Muhammad Atiq Ur Rehman, Rizwan Ahmed Malik, Hussein Alrobei

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引用次数: 0

Abstract

Skin burns are a major health concern that is caused by severe electric shocks, chemical and thermal exposure. The intense skin burns can cause the fibroblast cell death which can lead to the delayed wound healing. Direct ink write (DIW) printing is a promising three-dimensional (3D) printing technology that provides availability of different polymeric solutions and incorporation of bioactive agents within the polymeric blends with low material wastage. Herein, we fabricated a promising combination of ink consisting of sodium alginate (Na-ALG), guar gum (GG), and Ficus carica (FC) for DIW printing. The formulated scaffolds showed favorable rheological properties and layer fidelity. The scaffolds depicted appropriate intercrosslinked porous morphology that supported swelling ability. Na-ALG/GG/FC scaffolds were biodegradable, released gallic acid (GA) and demonstrated antibacterial efficacy against Escherichia coli and Staphylococcus aureus. Scaffold exhibited biocompatibility of 109% on Day 7 with fibroblasts and released vascular endothelial growth factor (VEGF) which indicated formation of new blood vessels. Hence, Na-ALG/GG/FC scaffolds are a potential candidate for treating chronic wounds.

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无花果提取物负载3d打印海藻酸钠/瓜尔胶支架用于潜在的伤口愈合应用：一项体外研究。

皮肤烧伤是严重触电、化学接触和热接触造成的主要健康问题。严重的皮肤烧伤可引起成纤维细胞死亡，从而导致伤口愈合延迟。直接墨水写入（DIW）打印是一种很有前途的三维（3D）打印技术，它提供了不同聚合物解决方案的可用性，并在聚合物混合物中加入了生物活性剂，材料浪费低。在此，我们制备了一种由海藻酸钠（Na-ALG），瓜尔胶（GG）和无花果（FC）组成的有前途的DIW印刷油墨组合。所制备的支架具有良好的流变性能和层保真度。支架具有适当的交联多孔形态，支持膨胀能力。Na-ALG/GG/FC支架可生物降解，释放没食子酸（GA），对大肠杆菌和金黄色葡萄球菌具有抗菌作用。第7天，支架与成纤维细胞的生物相容性达到109%，并释放血管内皮生长因子（VEGF），表明新血管的形成。因此，Na-ALG/GG/FC支架是治疗慢性伤口的潜在候选材料。

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来源期刊

ChemBioChem 生物-生化与分子生物学

CiteScore

6.10

自引率

3.10%

发文量

407

审稿时长

1 months

期刊介绍： ChemBioChem (Impact Factor 2018: 2.641) publishes important breakthroughs across all areas at the interface of chemistry and biology, including the fields of chemical biology, bioorganic chemistry, bioinorganic chemistry, synthetic biology, biocatalysis, bionanotechnology, and biomaterials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and supported by the Asian Chemical Editorial Society (ACES).