Efficiently robust transfer hydrogenation of nitriles to methylamines achieved by using manganese complexes

IF 6.5 1区化学 Q2 CHEMISTRY, PHYSICAL

Journal of Catalysis Pub Date : 2026-04-30 DOI:10.1016/j.jcat.2026.116925

Quanming Lyu, Xiaoyan Qian, Yi Su, Yizhou Wang, Libin Li, Zheng Wang, Yanping Ma, Wen-Hua Sun

引用次数: 0

Abstract

Series of manganese complexes bearing either NN-ligands (Mn1 – Mn4) or NNP/S-pincer ligands (Mn5 – Mn8), the latter varied with the fused cycles from six to eight members, were developed in achieving highly efficient hydrogenation of various nitriles into methylamine derivatives. The representative Mn6 showed an outstanding activity with its TON as 8500 and its TOF as 4250. Aryl- and alkyl-nitrile derivatives could be hydrogenated into their derivative methylamines being tolerant with some unsaturated groups; moreover, the potential application in synthesizing amine pharmacophores has been explored in gram scales. The easily prepared carbonyl-manganese complexes with definitive structures have been extensively investigated and reported.

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利用锰配合物实现了腈到甲胺的高效、稳健的转移加氢

为了实现各种腈基高效氢化成甲胺衍生物，开发了一系列含有nn -配体（Mn1 - Mn4）或NNP/ s -螯合配体（Mn5 - Mn8）的锰配合物，后者随融合循环从6到8个成员变化。具有代表性的Mn6的TON为8500，TOF为4250，具有较好的活性。芳基和烷基腈衍生物可氢化成对某些不饱和基团具有耐受性的甲胺衍生物；此外，还以克为单位探讨了其在合成胺类药效团方面的潜在应用。易于制备的具有明确结构的羰基-锰配合物已被广泛研究和报道。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Catalysis 工程技术-工程：化工

CiteScore

12.30

自引率

5.50%

发文量

447

审稿时长

31 days

期刊介绍： The Journal of Catalysis publishes scholarly articles on both heterogeneous and homogeneous catalysis, covering a wide range of chemical transformations. These include various types of catalysis, such as those mediated by photons, plasmons, and electrons. The focus of the studies is to understand the relationship between catalytic function and the underlying chemical properties of surfaces and metal complexes. The articles in the journal offer innovative concepts and explore the synthesis and kinetics of inorganic solids and homogeneous complexes. Furthermore, they discuss spectroscopic techniques for characterizing catalysts, investigate the interaction of probes and reacting species with catalysts, and employ theoretical methods. The research presented in the journal should have direct relevance to the field of catalytic processes, addressing either fundamental aspects or applications of catalysis.