Prevalencia de Demodex en pacientes con blefaritis y su asociación con la enfermedad de ojo seco

Q3 Medicine

Archivos De La Sociedad Espanola De Oftalmologia Pub Date : 2026-05-01 Epub Date: 2026-02-16 DOI:10.1016/j.oftal.2026.502464

D.L. Serrano Ramírez , J.M. Carrillo Martinez , R. Gútierrez Gómez , M.P. Serrano Ramírez , A. Carrasco Quiroz

{"title":"Prevalencia de Demodex en pacientes con blefaritis y su asociación con la enfermedad de ojo seco","authors":"D.L. Serrano Ramírez , J.M. Carrillo Martinez , R. Gútierrez Gómez , M.P. Serrano Ramírez , A. Carrasco Quiroz","doi":"10.1016/j.oftal.2026.502464","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and objective</h3><div>To determine the prevalence of <em>Demodex</em> in patients with blepharitis, its clinical characteristics, as well as its association with systemic conditions, and the type and severity of dry eye disease (DED).</div></div><div><h3>Materials and methods</h3><div>A cross-sectional, observational, and analytical study was conducted. 302 patients with signs of blepharitis were evaluated from December 2024 to April 2025 at a Mexican ophthalmology referral center.</div></div><div><h3>Results</h3><div>The prevalence of <em>Demodex</em> was 49.3%, with significant differences between age groups, observing a higher prevalence with advanced ages: 39.7% in <60years, and 49.3% in ≥60years (χ<sup>2</sup>   ≤.001). Regarding clinical characteristics, patients with <em>Demodex</em> had a higher presence of collarettes, a higher prevalence of mixed blepharitis (58.4%), and mixed dry eye disease (DED). Regarding tests for dry eye type and severity, there were only differences in the Van Bijsterveld score (χ<sup>2</sup>  <!-->0.009), but not for the TBUT, Schirmer, or OSDI scores.</div></div><div><h3>Conclusion</h3><div>Ocular demodicosis has a high prevalence in our population; its presence is associated with age, with no differences by gender. T2D increases the likelihood of developing <em>Demodex</em>. The anatomical and functional alterations caused by this ocular infection can promote or worsen the symptoms and severity of DED.</div></div>","PeriodicalId":8348,"journal":{"name":"Archivos De La Sociedad Espanola De Oftalmologia","volume":"101 5","pages":"Article 502464"},"PeriodicalIF":0.0000,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos De La Sociedad Espanola De Oftalmologia","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S036566912600002X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/16 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background and objective

To determine the prevalence of Demodex in patients with blepharitis, its clinical characteristics, as well as its association with systemic conditions, and the type and severity of dry eye disease (DED).

Materials and methods

A cross-sectional, observational, and analytical study was conducted. 302 patients with signs of blepharitis were evaluated from December 2024 to April 2025 at a Mexican ophthalmology referral center.

Results

The prevalence of Demodex was 49.3%, with significant differences between age groups, observing a higher prevalence with advanced ages: 39.7% in < 60 years, and 49.3% in ≥ 60 years (χ² = 0.009). Type 2 diabetes (T2D) was associated with a significant risk of developing demodicosis (OR: 2.456 (95% CI: 1.457-4.141), P ≤ .001). Regarding clinical characteristics, patients with Demodex had a higher presence of collarettes, a higher prevalence of mixed blepharitis (58.4%), and mixed dry eye disease (DED). Regarding tests for dry eye type and severity, there were only differences in the Van Bijsterveld score (χ² = 0.009), but not for the TBUT, Schirmer, or OSDI scores.

Conclusion

Ocular demodicosis has a high prevalence in our population; its presence is associated with age, with no differences by gender. T2D increases the likelihood of developing Demodex. The anatomical and functional alterations caused by this ocular infection can promote or worsen the symptoms and severity of DED.

查看原文本刊更多论文

蠕形螨在眼睑炎患者中的流行及其与干眼病的关联

背景与目的了解蠕形螨在眼炎患者中的流行情况、临床特征、与全身疾病的关系以及干眼病（DED）的类型和严重程度。材料与方法进行了横断面、观察性和分析性研究。从2024年12月到2025年4月，在墨西哥眼科转诊中心对302例有睑炎症状的患者进行了评估。结果蠕形螨阳性率为49.3%，年龄组间差异有统计学意义，年龄越大患病率越高，60岁及以上年龄组为39.7%，60岁及以上年龄组为49.3% （χ2 = 0.009）。2型糖尿病（T2D）与发生蠕虫病的显著风险相关（OR: 2.456 (95% CI: 1.457-4.141), P≤0.001）。在临床特征方面，蠕形螨患者有较高的结肠炎、混合性睑炎（58.4%）和混合性干眼病（DED）的患病率。关于干眼类型和严重程度的测试，只有Van Bijsterveld评分存在差异（χ2 = 0.009），但TBUT、Schirmer或OSDI评分没有差异。结论眼蠕虫病在我国人群中具有较高的患病率；它的存在与年龄有关，没有性别差异。T2D增加了发展蠕形螨的可能性。这种眼部感染引起的解剖和功能改变可促进或加重DED的症状和严重程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Archivos De La Sociedad Espanola De Oftalmologia Medicine-Ophthalmology

CiteScore

1.20

自引率

0.00%

发文量

109

审稿时长

78 days

期刊介绍： La revista Archivos de la Sociedad Española de Oftalmología, editada mensualmente por la propia Sociedad, tiene como objetivo publicar trabajos de investigación básica y clínica como artículos originales; casos clínicos, innovaciones técnicas y correlaciones clinicopatológicas en forma de comunicaciones cortas; editoriales; revisiones; cartas al editor; comentarios de libros; información de eventos; noticias personales y anuncios comerciales, así como trabajos de temas históricos y motivos inconográficos relacionados con la Oftalmología. El título abreviado es Arch Soc Esp Oftalmol, y debe ser utilizado en bibliografías, notas a pie de página y referencias bibliográficas.