Clinical characteristics and outcomes of Colombian patients with Takayasu arteritis: A retrospective cohort

IF 0.5 Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2026-04-01 Epub Date: 2026-02-04 DOI:10.1016/j.rcreu.2026.504868

Fabio Torres Saavedra , Lina León Sierra , Gloria Vásquez , Luis Alonso González Naranjo , Adriana Lucía Vanegas García , Carlos Horacio Muñoz Vahos

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Abstract

Introduction

Takayasu arteritis (TAK) is a vasculitis of the great vessels that affects mainly young patients. Cardiovascular morbidity is high due to irreversible damage, end-organ failure, and a late diagnosis. The knowledge of this vasculitis in our country is limited. This study describes clinical, laboratory, and angiographic findings of Takayasu arteritis in Colombia.

Methods

We described a retrospective cohort of patients with Takayasu arteritis in two rheumatology centers in Medellin, Colombia between 2011 and 2018. We assessed the medical records of 43 patients, 88% of whom met Takayasu arteritis 1990 ACR criteria.

Results

Of the forty-three patients, forty-one were female, with a median age of 22 years at diagnosis. Eleven patients were >40 years old. The median delay in diagnosis was 12 months. Systemic manifestations included general malaise (32%), weight loss (23%), and fever (21%). The most frequent vascular symptoms were headache (39%) and upper limb claudication (30%). The most frequent physical examination findings were absent or decreased pulses (76%), hypertension (62%), blood pressure difference (60%), and subclavian murmur (48%). Eighty three percent and 76% of patients had elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), respectively. Angiography (mainly magnetic resonance [MR] angiography) showed stenosis in the left subclavian artery (68%), followed by aortic involvement, including abdominal (62%) and thoracic (52%) segments. Hata–Numano's classification was V (62%), I (16%), and IIa (7%). Renal artery abnormalities, pulmonary artery stenosis, and aortic regurgitation were present in 42%, 14%, and 9%, respectively. Vascular complications were renovascular hypertension (30%), ischemic stroke, chronic kidney disease, and heart failure (all with 18%). Twenty-eight patients (65%) completed the 5-year follow-up. The overall survival rate was 83% in the fifth year, compared to 87.5% in the first.

Conclusions

A high rate of complicated vascular lesions (Hata–Numano V and renal/splanchnic artery disease), ongoing disease activity, and a late diagnosis may be the causes of the increased morbidity observed in this cohort of TAK patients.

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哥伦比亚高须动脉炎患者的临床特征和预后：一项回顾性队列研究

takayasu动脉炎（taku arteritis， TAK）是一种主要影响年轻患者的大血管血管炎。由于不可逆的损害、终末器官衰竭和较晚的诊断，心血管疾病的发病率很高。我国对这种血管炎的认识有限。本研究描述了哥伦比亚高须动脉炎的临床、实验室和血管造影结果。方法：我们对2011年至2018年在哥伦比亚麦德林的两个风湿病中心的高松动脉炎患者进行了回顾性队列研究。我们评估了43例患者的病历，其中88%的患者符合Takayasu动脉炎1990年ACR标准。结果43例患者中，女性41例，确诊时中位年龄22岁。11例患者年龄为40岁。诊断延迟的中位数为12个月。全身性表现包括全身不适（32%）、体重减轻（23%）和发烧（21%）。最常见的血管症状是头痛（39%）和上肢跛行（30%）。最常见的体检结果是脉搏缺失或减少（76%）、高血压（62%）、血压差（60%）和锁骨下杂音（48%）。分别有83%和76%的患者红细胞沉降率（ESR）和c反应蛋白（CRP）升高。血管造影（主要是磁共振[MR]血管造影）显示左侧锁骨下动脉狭窄（68%），其次是主动脉受累，包括腹段（62%）和胸段（52%）。Hata-Numano分型为V型（62%）、I型（16%）、IIa型（7%）。肾动脉异常、肺动脉狭窄和主动脉反流分别为42%、14%和9%。血管并发症包括肾血管性高血压（30%）、缺血性中风、慢性肾病和心力衰竭（均为18%）。28例患者（65%）完成了5年随访。第5年的总生存率为83%，而第1年为87.5%。结论高比例的复杂血管病变（Hata-Numano V和肾/胰腺动脉病变）、持续的疾病活动和较晚的诊断可能是该队列TAK患者发病率增加的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.