Vasculitis asociada a ANCAs con compromiso pulmonar severo como efecto adverso del propiltiouracilo. Reporte de caso

IF 0.5 Q3 Health Professions

Revista Colombiana de Reumatologia Pub Date : 2026-04-01 Epub Date: 2026-02-05 DOI:10.1016/j.rcreu.2026.504866

José S. Cortés , Javier Alejandro Correa , Wilder Carvajal , Wilmer Aponte , Luis Javier Cajas

引用次数: 0

Abstract

Introduction

Propylthiouracil (PTU) is used to treat Graves’ disease and has been reported to induce antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

Case report

A 54-year-old woman with Graves’ disease developed PTU-associated AAV, manifested by diffuse alveolar hemorrhage complicated by pneumonia and pleural effusion. As part of her treatment, she received methylprednisolone, prednisolone, and rituximab. The patient showed remarkable pulmonary recovery at three-month follow-up.

Conclusions

This case highlights the importance of early recognition of PTU-induced AAV and the progression of a severe pulmonary complication.

查看原文本刊更多论文

与ANCAs相关的血管炎，作为丙硫脲嘧啶的副作用，严重影响肺部。案例报告

丙基硫脲嘧啶（PTU）用于治疗Graves病，有报道称其可诱导抗中性粒细胞细胞质抗体（ANCA）相关血管炎（AAV）。病例报告：一名54岁女性Graves病患者发展为肺动脉相关性AAV，表现为弥漫性肺泡出血并发肺炎和胸腔积液。作为治疗的一部分，她接受了甲基强的松龙、强的松龙和利妥昔单抗。随访3个月，患者肺功能明显恢复。结论该病例强调了早期识别ptu诱导的AAV和严重肺部并发症进展的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Revista Colombiana de Reumatologia Medicine-Rheumatology

CiteScore

0.80

自引率

0.00%

发文量

期刊介绍： The Colombian Journal of Rheumatology (Revista Colombiana de Reumatología) is the official organ of the Colombian Association of Rheumatology (Asociación Colombiana de Reumatología) and the Central American, Caribbean and Andean Association of Rheumatology (Asociación Centroamericana Caribe Andina de Reumatología) - ACCA. It was created in December 1993 with the purpose of disseminating scientific information derived from primary and secondary research and presenting cases coming from the practice of Rheumatology in Latin America. Since its foundation, the Journal has been characterized by its plurality with subjects of all rheumatic and osteomuscular pathologies, in the form of original articles, historical articles, economic evaluations, and articles of reflection and education in Medicine. It covers an extensive area of topics ranging from the broad spectrum of the clinical aspects of rheumatology and related areas in autoimmunity (both in pediatric and adult pathologies), to aspects of basic sciences. It is an academic tool for the different members of the academic and scientific community at their different levels of training, from undergraduate to post-doctoral degrees, managing to integrate all actors inter and trans disciplinarily. It is intended for rheumatologists, general internists, specialists in related areas, and general practitioners in the country and abroad. It has become an important space in the work of all rheumatologists from Central and South America.