Novel sesquiterpenes and polyketides from the fungi Corynespora sp. YG-11 and Penicillium rubens YG-2 promote tobacco growth and enhance its stress resistance

IF 6.2 1区农林科学 Q1 AGRICULTURAL ENGINEERING

Industrial Crops and Products Pub Date : 2026-05-01 Epub Date: 2026-04-25 DOI:10.1016/j.indcrop.2026.123318

Jing Sun , Chuanmei Yi , Xuechan Yang , Fangyan Li , Xu Zheng , Zihao Xue , Yabin Yang , Zhongtao Ding , Xueqiong Yang

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Abstract

The deterioration of tobacco (Nicotiana tabacum L.) quality and yield is caused by abiotic stress (temperature, salt, heavy metals, etc.) and biotic stress (plant pathogens). The growth-promoting and stress resistance-enhancing compounds were isolated from endophytic fungi Corynespora sp. YG-11 and Penicillium rubens YG-2, both derived from tobacco tissue culture seedlings. One unprecedented sesquiterpene-cyclohexenone hybrid skeleton, corynecaserpene A (1), seventeen undescribed sesquiterpenes， corynecaserpenes B-R (2-18), a novel alkaloid, corynecapenoid A (19), and three known compounds (24-25, and 29) from Corynespora sp. Four unreported polyketides, peniciruketides A-D (20-23), and three known compounds (26-28) from Penicillium rubens. The chemical structures were conclusively elucidated by spectroscopic analysis, ECD calculation, DP4 + analysis, Mosher’s method, and single-crystal X-ray diffraction (SXRD). The growth-promoting and stress resistance-enhancing activities of the compounds on tobacco seedlings were evaluated, and the results indicated that cyclohexenoneterpene F (27) exerted a significant growth-promoting effect on the shoot and root lengths of tobacco seedlings in the absence of stress. Corynecaserpene F (6) and fumiparaphine B (29) showed prominent stress-mitigating activity in tobacco seedlings under abiotic stresses (salt, low temperature), and corynecaserpenes B (2), J (10) and peniciruketide A (20) exhibited a significant alleviating effect on both abiotic stresses and biotic stress (plant pathogen) in tobacco seedlings. Additionally, cyclohexenoneterpene F (27) exhibited significant antifungal activity against Cladosporium sp., showing a mycelial growth inhibition rate of 68% at 30 μg/mL. The structure-activity relationship of the compounds regarding their growth-promoting activity on tobacco seedlings were discussed.

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从真菌Corynespora sp. YG-11和Penicillium rubens YG-2中提取的新型倍半萜和多酮类物质促进烟草生长，增强其抗旱性

烟草（Nicotiana tabacum L.）品质和产量的恶化是由非生物胁迫（温度、盐、重金属等）和生物胁迫（植物病原体）引起的。从烟草组培苗内生真菌Corynespora sp. YG-11和Penicillium rubens YG-2中分离得到促生长和抗胁迫化合物。一个前所未有的倍半萜-环己酮杂交骨架，青霉霉烯A(1)， 17个未描述的倍半萜，青霉霉烯B-R(2-18)，一个新的生物碱，青霉烯A(19)，三个已知的化合物（24-25和29），四个未报道的多酮，青霉烯A- d(20-23)，三个已知的化合物（26-28）。通过光谱分析、ECD计算、DP4 + 分析、Mosher法和单晶x射线衍射（SXRD）对其化学结构进行了最终的鉴定。结果表明，在无胁迫条件下，环己烯萜烯F（27）对烟草幼苗的茎长和根长均有显著的促生长作用。在非生物胁迫（盐、低温）下，青霉茄烯F(6)和烟米帕素B（29）在烟草幼苗中表现出显著的抗逆性，青霉茄烯B(2)、J（10）和青霉酮A（20）对烟草幼苗的非生物胁迫和生物胁迫（植物病原菌）均表现出显著的抗逆性。此外，环己烯萜F（27）对枝孢杆菌（Cladosporium sp.）表现出显著的抗真菌活性，在30 μg/mL浓度下对菌丝生长的抑制率为68%。讨论了化合物对烟草幼苗促生长活性的构效关系。

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来源期刊

Industrial Crops and Products 农林科学-农业工程

CiteScore

9.50

自引率

8.50%

发文量

1518

审稿时长

43 days

期刊介绍： Industrial Crops and Products is an International Journal publishing academic and industrial research on industrial (defined as non-food/non-feed) crops and products. Papers concern both crop-oriented and bio-based materials from crops-oriented research, and should be of interest to an international audience, hypothesis driven, and where comparisons are made statistics performed.