O 2 ‐Mediated Cu‐Catalyzed Dehydrogenative Sulfilimination of Tyrosines and Bioactive Phenols

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2026-04-27 DOI:10.1002/adsc.70420

Fang Xiao, Frederic W. Patureau

引用次数: 0

Abstract

The bioconjugation of unmodified native peptides, in particular at their tyrosine units with the dehydrogenative phenochalcogenazination reaction, has attracted much attention lately due to potential click type applications. In our quest to bring this oxidative coupling concept beyond phenothiazines and its derivatives, we report herein the case of sulfenamides and their mild O 2 ‐mediated Cu‐catalyzed dehydrogenative sulfilimination of diverse bioactive phenols.

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O - 2介导的Cu -催化酪氨酸和生物活性酚的脱氢磺化反应

未经修饰的天然多肽的生物偶联，特别是在其酪氨酸单元与脱氢酚醛化反应，近年来引起了广泛的关注，因为潜在的点击型应用。为了将这种氧化偶联概念超越吩噻嗪类及其衍生物，我们在此报告了亚砜酰胺及其温和的o2介导的Cu催化的多种生物活性酚的脱氢亚砜化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.