Validation of the estimation of 192Ir production rates in wires from natural iridium-platinum in research reactors

IF 1.6 3区化学 Q3 CHEMISTRY, ANALYTICAL

Journal of Radioanalytical and Nuclear Chemistry Pub Date : 2026-04-02 DOI:10.1007/s10967-026-10783-6

P. Tataje, B. Ticona, S. Daza, Anais Adauto

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Abstract

Iridium-192 is a crucial radionuclide, extensively used in brachytherapy for cancer treatment. The accurate estimation of the production rate of ¹⁹²Ir is critical for optimizing the manufacture of brachytherapy sources in nuclear reactors and ensuring their dosimetric quality. A rigorous calculation of this rate makes it possible to define irradiation times, guarantee the activity required at the clinical moment, and reduce variations in production, all of which have a direct impact on therapeutic efficacy. This study evaluates the production rate of ¹⁹²Ir in wires composed of natural iridium-platinum alloys when irradiated in research reactors. The methodology incorporates the Hϕgdhal convention, taking into account neutron flux distribution, cross-section data, self-shielding factor, and resonance integral estimations. Experimental validation is carried out through neutron activation analysis and gamma spectroscopy using a HPGe detector. The results demonstrate a strong correlation between theoretical calculations and experimental measurements, providing a reliable framework for optimizing ¹⁹²Ir production.

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研究反应器中天然铱铂金属丝192Ir产率估算的验证

铱-192是一种重要的放射性核素，广泛用于近距离放射治疗癌症。准确估计192Ir的生成速率对于优化核反应堆近距离放射治疗源的制造和确保其剂量学质量至关重要。严格计算这一比率可以确定照射时间，保证临床所需的活动，并减少生产变化，所有这些都对治疗效果有直接影响。本研究评估了在研究堆中辐照天然铱-铂合金组成的金属丝中产生192Ir的速率。该方法结合了Hϕgdhal惯例，考虑到中子通量分布，截面数据，自屏蔽因子和共振积分估计。通过中子活化分析和能谱分析，利用HPGe探测器进行了实验验证。结果表明，理论计算和实验测量之间具有很强的相关性，为优化192Ir生产提供了可靠的框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Radioanalytical and Nuclear Chemistry 化学-分析化学

CiteScore

2.80

自引率

18.80%

发文量

504

审稿时长

2.2 months

期刊介绍： An international periodical publishing original papers, letters, review papers and short communications on nuclear chemistry. The subjects covered include: Nuclear chemistry, Radiochemistry, Radiation chemistry, Radiobiological chemistry, Environmental radiochemistry, Production and control of radioisotopes and labelled compounds, Nuclear power plant chemistry, Nuclear fuel chemistry, Radioanalytical chemistry, Radiation detection and measurement, Nuclear instrumentation and automation, etc.