Oral Cryptococcosis due to Naganishia diffluens in a Patient With Thalassemia: A Case Report and a Literature Review.

IF 2.9 4区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Journal of Clinical Laboratory Analysis Pub Date : 2026-04-21 DOI:10.1002/jcla.70234

Zahra Yahyazadeh, Zeynab Haseli, Javad Javidnia, Mahdi Abastabar, Eisa Nazar, Hosein Jalali, Mohamad Taghi Hedayati, Hossein Karami, Mohsen Nosratabadi, Lotfollah Davoodi, Seyyed Reza Aghili, Maryam Moazeni, Iman Haghani, Hamid Badali

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引用次数: 0

Abstract

Background: Naganishia diffluens (formerly Cryptococcus diffluens) is a non-neoformans cryptococcal species rarely isolated as a human pathogen. We reported a case of oral cryptococcosis caused by N. diffluens for the first time and reviewed relevant literature.

Methods: Herein, we present the case of a 31-year-old Iranian male with a history of major β-thalassemia, who presented with non-hemorrhagic white spots on the buccal mucosa, the mouth, lips, and the tongue's surface. Abdominal ultrasound results of the pelvis and abdomen showed that the patient has significant splenomegaly. Two consecutive samples were collected from the white spots on the patient's tongue to confirm the infection, which was confirmed via PCR Sequencing analysis.

Results: In both sampling occasions, Naganishia diffluens was isolated as the causative organism. According to a review conducted in PubMed, Web of Science, and Scopus for data analysis of oral cryptococcosis, just 27 reports were described in the literature. Naganishia diffluens can be the causative agent of some infections.

Conclusion: This is the first report of oral cryptococcosis due to N. diffluens successfully detected by DNA sequencing. However, to understand the precise prevalence of this emerging pathogen, epidemiological surveillance studies are highly recommended.

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地中海贫血患者口腔隐球菌感染：1例报告及文献复习。

背景：长岛散流隐球菌（原散流隐球菌）是一种作为人类病原体很少分离的非新生隐球菌。我们首次报道了一例由扩散奈瑟菌引起的口腔隐球菌病，并对相关文献进行了复习。方法：在此，我们报告了一例31岁伊朗男性，有严重β-地中海贫血史，他表现为颊粘膜、口腔、嘴唇和舌头表面的非出血性白斑。骨盆及腹部超声检查显示患者脾肿大。对患者舌部白斑连续2次采集标本确认感染，经PCR测序分析确认感染。结果：两次取样均分离出长岛散流菌为病原菌。根据PubMed、Web of Science和Scopus对口腔隐球菌病数据分析的回顾，文献中只有27份报告被描述。长岛扩散物可能是某些感染的病原体。结论：这是首次通过DNA测序成功检测到口腔隐球菌病。然而，为了准确了解这种新发病原体的流行情况，强烈建议开展流行病学监测研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Laboratory Analysis 医学-医学实验技术

CiteScore

5.60

自引率

7.40%

发文量

584

审稿时长

6-12 weeks

期刊介绍： Journal of Clinical Laboratory Analysis publishes original articles on newly developing modes of technology and laboratory assays, with emphasis on their application in current and future clinical laboratory testing. This includes reports from the following fields: immunochemistry and toxicology, hematology and hematopathology, immunopathology, molecular diagnostics, microbiology, genetic testing, immunohematology, and clinical chemistry.