Uptake and Retention of Laser-synthesized Boron Nanoparticles in Tumor Cells and Fibroblasts.

IF 0.7 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Doklady Biochemistry and Biophysics Pub Date : 2026-04-20 DOI:10.1134/S1607672925601775

A I Kasatova, K S Kuzmina, P A Kotelnikova, E V Barmina, K O Aiyyzhy, A A Laktionov, D I Tselikov, I V Sozaev, I V Lunyov, S M Klimentov, M S Grigoryeva, D S Petrunya, E L Zavjalov, S Yu Taskaev, S M Deyev, I N Zavestovskaya

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引用次数: 0

Abstract

Boron Neutron Capture Therapy (BNCT) is one of the innovative methods for treating oncological diseases. Its selectivity is based on the targeted delivery of the boron-10 isotope to tumor cells, followed by neutron irradiation, the ¹⁰B(n, α)⁷Li reaction occurs with a local release of 2.79 MeV of energy. Budding boron delivery agents are nanoscale systems. This study evaluated in vitro cytotoxicity, accumulation, and retention of elemental boron nanoparticles, synthesized by laser ablation and laser fragmentation, in U87 and BT474 tumor cells and BJ-5ta fibroblasts. It was shown that both types of nanoparticles exhibit low cytotoxicity at therapeutically relevant concentrations. Boron accumulation was maximal after 24 h of incubation and was significantly higher in tumor cells, especially in the BT474 cell line, compared to fibroblasts. The obtained data indicate the promise of these nanoparticles as boron delivery agents for BNCT.

查看原文本刊更多论文

激光合成的硼纳米颗粒在肿瘤细胞和成纤维细胞中的吸收和保留。

硼中子俘获疗法（BNCT）是治疗肿瘤疾病的创新方法之一。它的选择性是基于硼-10同位素靶向递送到肿瘤细胞，然后中子照射，10B(n, α)7Li反应发生，局部释放2.79 MeV的能量。出芽硼输送剂是纳米级系统。本研究评估了通过激光烧蚀和激光碎裂合成的元素硼纳米颗粒在U87和BT474肿瘤细胞以及BJ-5ta成纤维细胞中的体外细胞毒性、积累和保留。研究表明，两种类型的纳米颗粒在治疗相关浓度下均表现出较低的细胞毒性。与成纤维细胞相比，硼在肿瘤细胞，尤其是BT474细胞系中的积累量在培养24小时后达到最大。所获得的数据表明，这些纳米颗粒有望作为BNCT的硼递送剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Doklady Biochemistry and Biophysics 生物-生化与分子生物学

CiteScore

1.60

自引率

12.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Doklady Biochemistry and Biophysics is a journal consisting of English translations of articles published in Russian in biochemistry and biophysics sections of the Russian-language journal Doklady Akademii Nauk. The journal''s goal is to publish the most significant new research in biochemistry and biophysics carried out in Russia today or in collaboration with Russian authors. The journal accepts only articles in the Russian language that are submitted or recommended by acting Russian or foreign members of the Russian Academy of Sciences. The journal does not accept direct submissions in English.